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    MDH2 malate dehydrogenase MDH2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853994, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MDH2
    Official Full Name
    malate dehydrogenase MDH2
    Primary source
    SGD:S000005486
    Locus tag
    YOL126C
    See related
    AllianceGenome:SGD:S000005486; FungiDB:YOL126C; VEuPathDB:YOL126C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-malate dehydrogenase (NAD+) activity. Involved in gluconeogenesis and protein import into peroxisome matrix. Located in cytosol and nuclear periphery. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MDH2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (81787..82920, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase YGK3 Neighboring gene ribosomal 60S subunit protein L25 Neighboring gene tRNA:m4X modification enzyme Neighboring gene tRNA (guanine-N2-)-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo and in vitro studies on the glucose dependent inactivation of yeast cytoplasmic malate dehydrogenase. Neeff J, et al. Arch Microbiol, 1977 Oct 24. PMID 337921
    2. Glucose-induced degradation of the MDH2 isozyme of malate dehydrogenase in yeast. Minard KI, et al. J Biol Chem, 1992 Aug 25. PMID 1324938
    3. Glucose-induced phosphorylation of the MDH2 isozyme of malate dehydrogenase in Saccharomyces cerevisiae. Minard KI, et al. Arch Biochem Biophys, 1994 Dec. PMID 7986072
    4. Application of an immunoassay to the study of yeast malate dehydrogenase inactivation. Neeff J, et al. Biochem Biophys Res Commun, 1978 Jan 13. PMID 341893
    5. Imaging-based live cell yeast screen identifies novel factors involved in peroxisome assembly. Wolinski H, et al. J Proteome Res, 2009 Jan. PMID 19118449

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A piggybacking mechanism enables peroxisomal localization of the glyoxylate cycle enzyme Mdh2 in yeast.
      Title: A piggybacking mechanism enables peroxisomal localization of the glyoxylate cycle enzyme Mdh2 in yeast.
    2. fructose-1,6-bisphosphatase and malate dehydrogenase degradation is mediated by distinct proteolytic pathways and signaling events
      Title: Degradation of the gluconeogenic enzymes fructose-1,6-bisphosphatase and malate dehydrogenase is mediated by distinct proteolytic pathways and signaling events.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-malate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-malate dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-malate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-malate dehydrogenase (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in malate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    malate dehydrogenase MDH2
    NP_014515.2
    • Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1; mutation in human homolog MDH2 causes early-onset severe encephalopathy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      81787..82920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183380.1 → NP_014515.2  TPA: malate dehydrogenase MDH2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014515.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1U2, P22133
      UniProtKB/TrEMBL
      C7GV03, C8ZHJ0, N1NX84
      Conserved Domains (1) summary
      TIGR01772
      Location:15 → 372
      MDH_euk_gproteo; malate dehydrogenase, NAD-dependent
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22133.2

    Gene LinkOut

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