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    dfr1 dihydrofolate reductase/ lysophospholipase fusion protein Dfr1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539048, updated on 22-Jun-2024

    Summary

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    Gene symbol
    dfr1
    Gene description
    dihydrofolate reductase/ lysophospholipase fusion protein Dfr1
    Locus tag
    SPOM_SPCC1223.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPCC1223.08c
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    Genomic context

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    See dfr1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1855295..1857115)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene aspartate--tRNA (Asp) ligase Drs1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uricase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The isolation and characterization of the gene (dfr1) encoding dihydrofolate reductase (DHFR) in Schizosaccharomyces pombe. Bertani LE, et al. Gene, 1994 Sep 15. PMID 8088538
    2. FSH1 encodes lysophospholipase activity in Saccharomyces cerevisiae. Ramachandran G, et al. Biotechnol Lett, 2021 Jan. PMID 32920715
    3. The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring. Roberts-Galbraith RH, et al. J Cell Biol, 2009 Jan 12. PMID 19139265, Free PMC Article
    4. Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4. Anderson HE, et al. PLoS One, 2010 Oct 18. PMID 20976105, Free PMC Article
    5. Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site. Roberts-Galbraith RH, et al. Mol Cell, 2010 Jul 9. PMID 20603077, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydrofolate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydrofolate reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables lysophospholipase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dihydrofolate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in folic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tetrahydrofolate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dihydrofolate reductase/ lysophospholipase fusion protein Dfr1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1855295..1857115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023344.3 → NP_588353.1  dihydrofolate reductase/ lysophospholipase fusion protein Dfr1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588353.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74408, P36591
      Conserved Domains (2) summary
      cd00209
      Location:234 → 424
      DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
      pfam03959
      Location:1 → 215
      FSH1; Serine hydrolase (FSH1)
    Nucleotide Protein
    Heading Accession and Version

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