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    pcs2 phytochelatin synthetase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543367, updated on 22-Jun-2024

    Summary

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    Gene symbol
    pcs2
    Gene description
    phytochelatin synthetase
    Locus tag
    SPOM_SPAC3H1.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    pcs
    Old locus tag
    SPAC3H1.10
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    Genomic context

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    See pcs2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (1949678..1951508)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene vacuolar amino acid transmembrane transporter Avt3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization and functional characterization of metal-binding sites in phytochelatin synthases. Maier T, et al. Planta, 2003 Dec. PMID 12905027
    2. A common highly conserved cadmium detoxification mechanism from bacteria to humans: heavy metal tolerance conferred by the ATP-binding cassette (ABC) transporter SpHMT1 requires glutathione but not metal-chelating phytochelatin peptides. Prévéral S, et al. J Biol Chem, 2009 Feb 20. PMID 19054771
    3. Phytochelatin synthase genes from Arabidopsis and the yeast Schizosaccharomyces pombe. Ha SB, et al. Plant Cell, 1999 Jun. PMID 10368185, Free PMC Article
    4. Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration. Sooksa-Nguan T, et al. J Biol Chem, 2009 Jan 2. PMID 19001374
    5. Tolerance to toxic metals by a gene family of phytochelatin synthases from plants and yeast. Clemens S, et al. EMBO J, 1999 Jun 15. PMID 10369673, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cadmium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione gamma-glutamylcysteinyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione gamma-glutamylcysteinyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione gamma-glutamylcysteinyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular detoxification of cadmium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular detoxification of cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detoxification of copper ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detoxification of copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phytochelatin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phytochelatin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phytochelatin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    phytochelatin synthetase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1949678..1951508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018985.3 → NP_593552.1  phytochelatin synthetase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593552.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10075
      Conserved Domains (1) summary
      pfam05023
      Location:43 → 250
      Phytochelatin; Phytochelatin synthase
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials