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    CDC27 anaphase promoting complex subunit CDC27 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852194, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDC27
    Official Full Name
    anaphase promoting complex subunit CDC27
    Primary source
    SGD:S000000180
    Locus tag
    YBL084C
    See related
    AllianceGenome:SGD:S000000180; FungiDB:YBL084C; VEuPathDB:YBL084C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    APC3; SNB1
    Summary
    Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process and protein ubiquitination. Located in nuclear periphery. Part of anaphase-promoting complex. Orthologous to human CDC27 (cell division cycle 27). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CDC27 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (67169..69445, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Boi1p Neighboring gene dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture. Zhang Z, et al. J Mol Biol, 2010 Apr 16. PMID 20206185
    2. The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle. Heichman KA, et al. Cell, 1996 Apr 5. PMID 8620535
    3. Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast. Tan GS, et al. Cell Div, 2013 Jul 1. PMID 23816140, Free PMC Article
    4. Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis. Lamb JR, et al. EMBO J, 1994 Sep 15. PMID 7925276, Free PMC Article
    5. Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition. Passmore LA, et al. EMBO Rep, 2005 Sep. PMID 16113654, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anaphase promoting complex subunit CDC27
    NP_009469.2
    • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      67169..69445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178324.2 → NP_009469.2  TPA: anaphase promoting complex subunit CDC27 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009469.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPS0, P38042
      UniProtKB/TrEMBL
      G2W8S9, N1P6P8
      Conserved Domains (3) summary
      TIGR02917
      Location:500 → 741
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:540 → 568
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:39 → 126
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38042.2

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