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    iec1 Ino80 complex subunit Iec1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542854, updated on 22-Jun-2024

    Summary

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    Gene symbol
    iec1
    Gene description
    Ino80 complex subunit Iec1
    Locus tag
    SPOM_SPAC144.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPAC144.02
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    Genomic context

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    See iec1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4653049..4654387)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Schizosaccharomyces specific protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene adenylosuccinate synthetase Ade2 Neighboring gene ncRNA Neighboring gene ornithine decarboxylase Spe1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Ino80 complex mediates epigenetic centromere propagation via active removal of histone H3. Choi ES, et al. Nat Commun, 2017 Sep 13. PMID 28904333, Free PMC Article
    2. Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast. Tay Z, et al. PLoS One, 2013. PMID 23365689, Free PMC Article
    3. Fission yeast Iec1-ino80-mediated nucleosome eviction regulates nucleotide and phosphate metabolism. Hogan CJ, et al. Mol Cell Biol, 2010 Feb. PMID 19933844, Free PMC Article
    4. The INO80 Complex Regulates Epigenetic Inheritance of Heterochromatin. Shan CM, et al. Cell Rep, 2020 Dec 29. PMID 33378674, Free PMC Article
    5. Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast. Nguyen TT, et al. Sci Rep, 2015 Feb 11. PMID 25669599, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This suggests that the Iec1-Ino80 complex promotes transcription through nucleosome eviction.
      Title: Fission yeast Iec1-ino80-mediated nucleosome eviction regulates nucleotide and phosphate metabolism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair-dependent chromatin remodeling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ino80 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ino80 complex subunit Iec1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4653049..4654387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020092.3 → NP_594663.1  Ino80 complex subunit Iec1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594663.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UTM0
      Conserved Domains (3) summary
      COG5048
      Location:1 → 249
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:108 → 129
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:92 → 119
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version

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