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    MRT4 Mrt4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853860, updated on 3-Nov-2024

    Summary

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    Official Symbol
    MRT4
    Official Full Name
    Mrt4p
    Primary source
    SGD:S000001492
    Locus tag
    YKL009W
    See related
    AllianceGenome:SGD:S000001492; FungiDB:YKL009W; VEuPathDB:YKL009W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable large ribosomal subunit rRNA binding activity. Involved in nuclear-transcribed mRNA catabolic process and ribosome biogenesis. Located in nucleolus and nucleoplasm. Part of preribosome, large subunit precursor. Orthologous to human MRTO4 (MRT4 homolog, ribosome maturation factor). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MRT4 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (426242..426952)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene cruciform cutting endonuclease Neighboring gene putative ubiquitin-protein ligase UFD4 Neighboring gene sphingosine N-acyltransferase LAC1 Neighboring gene Cap1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions of ribosome maturation factors Yvh1 and Mrt4 influence mRNA decay, glycogen accumulation, and the expression of early meiotic genes in Saccharomyces cerevisiae. Sugiyama M, et al. J Biochem, 2011 Jul. PMID 21474464
    2. Subcellular localization of ribosomal P0-like protein MRT4 is determined by its N-terminal domain. Michalec B, et al. Int J Biochem Cell Biol, 2010 May. PMID 20083226
    3. Carboxy terminal modifications of the P0 protein reveal alternative mechanisms of nuclear ribosomal stalk assembly. Francisco-Velilla R, et al. Nucleic Acids Res, 2013 Oct. PMID 23880660, Free PMC Article
    4. Temperature-sensitive mutations in the Saccharomyces cerevisiae MRT4, GRC5, SLA2 and THS1 genes result in defects in mRNA turnover. Zuk D, et al. Genetics, 1999 Sep. PMID 10471698, Free PMC Article
    5. The amino terminal domain from Mrt4 protein can functionally replace the RNA binding domain of the ribosomal P0 protein. Rodríguez-Mateos M, et al. Nucleic Acids Res, 2009 Jun. PMID 19346338, Free PMC Article

    See all (139) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the interaction between Mrt4 and Yvh1 is also essential for normal glycogen accumulation and mRNA decay as well as the induction of sporulation genes
      Title: Genetic interactions of ribosome maturation factors Yvh1 and Mrt4 influence mRNA decay, glycogen accumulation, and the expression of early meiotic genes in Saccharomyces cerevisiae.
    2. loss of function of Mrt4 results in a deficit in 60S subunits, which is apparently due to impaired rRNA processing of 27S precursors
      Title: Role and dynamics of the ribosomal protein P0 and its related trans-acting factor Mrt4 during ribosome assembly in Saccharomyces cerevisiae.
    3. Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0.
      Title: Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0.
    4. results indicate that Mrt4 and P0 bind to the same site in the 25S rRNA.
      Title: The amino terminal domain from Mrt4 protein can functionally replace the RNA binding domain of the ribosomal P0 protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables large ribosomal subunit rRNA binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mrt4p
    NP_012916.1
    • Protein involved in mRNA turnover and ribosome assembly; required at post-transcriptional step for efficient retrotransposition; localizes to the nucleolus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      426242..426952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179575.1 → NP_012916.1  TPA: Mrt4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012916.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXS7, P33201
      UniProtKB/TrEMBL
      A6ZZV6, B3LR75, B5VME4, C7GRG8, C8ZCF7, G2WI22, N1P0D5
      Conserved Domains (1) summary
      cd05796
      Location:21 → 196
      Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33201.1

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