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    MSM1 methionine--tRNA ligase MSM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853081, updated on 29-Jun-2024

    Summary

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    Gene symbol
    MSM1
    Gene description
    methionine--tRNA ligase MSM1
    Primary source
    FungiDB:YGR171C
    Locus tag
    YGR171C
    See related
    SGD:S000003403; AllianceGenome:SGD:S000003403; VEuPathDB:YGR171C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables methionine-tRNA ligase activity. Involved in methionyl-tRNA aminoacylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MSM1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (840824..842551, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Lso2p Neighboring gene phosphatidylserine decarboxylase 2 Neighboring gene transporter YIP1 Neighboring gene Rbg2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of MSM1, the structural gene for yeast mitochondrial methionyl-tRNA synthetase. Tzagoloff A, et al. Eur J Biochem, 1989 Feb 1. PMID 2645139
    2. Yeast cytoplasmic and mitochondrial methionyl-tRNA synthetases: two structural frameworks for identical functions. Senger B, et al. J Mol Biol, 2001 Aug 3. PMID 11469869
    3. Purification of the yeast mitochondrial methionyl-tRNA synthetase. Common and distinctive features of the cytoplasmic and mitochondrial isoenzymes. Schwob E, et al. Eur J Biochem, 1988 Dec 1. PMID 3060359
    4. Incorporation of the Arc1p tRNA-binding domain to the catalytic core of MetRS can functionally replace the yeast Arc1p-MetRS complex. Karanasios E, et al. J Mol Biol, 2008 Sep 5. PMID 18598703
    5. Molecular determinants of the yeast Arc1p-aminoacyl-tRNA synthetase complex assembly. Karanasios E, et al. J Mol Biol, 2007 Dec 7. PMID 17976650

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methionyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionyl-tRNA aminoacylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methionine--tRNA ligase MSM1
    NP_011687.1
    • Mitochondrial methionyl-tRNA synthetase (MetRS); functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      840824..842551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181300.1 → NP_011687.1  TPA: methionine--tRNA ligase MSM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011687.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUV5, P22438
      UniProtKB/TrEMBL
      A0A8H4C2Z6, A6ZUI3, B3LI59, B5VJB6, C7GQ78, C8Z967, N1P2F5
      Conserved Domains (1) summary
      TIGR00398
      Location:15 → 550
      metG; methionine--tRNA ligase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22438.2

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