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    msd1 microtubule-anchoring factor Msd1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539908, updated on 18-Sep-2024

    Summary

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    Official Symbol
    msd1
    Official Full Name
    microtubule-anchoring factor Msd1
    Primary source
    PomBase:SPBC13E7.06
    Locus tag
    SPOM_SPBC13E7.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mug172
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    Genomic context

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    See msd1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3050551..3051959)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F1-ATPase delta subunit atp16 Neighboring gene pig-M family mannosyltransferase Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II-associated Paf1 complex protein Leo1 Neighboring gene verprolin Neighboring gene transcription factor TFIIIB subunit Brf1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gamma-tubulin complex-mediated anchoring of spindle microtubules to spindle-pole bodies requires Msd1 in fission yeast. Toya M, et al. Nat Cell Biol, 2007 Jun. PMID 17486116
    2. Loss of kinesin-14 results in aneuploidy via kinesin-5-dependent microtubule protrusions leading to chromosome cut. Syrovatkina V, et al. Nat Commun, 2015 Jun 2. PMID 26031557, Free PMC Article
    3. The Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies. Yukawa M, et al. J Cell Biol, 2015 May 25. PMID 25987607, Free PMC Article
    4. Identification of 15 New Bypassable Essential Genes of Fission Yeast. Takeda A, et al. Cell Struct Funct, 2019 Sep 27. PMID 31474649, Free PMC Article
    5. Suppressor Analysis Uncovers That MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly in Schizosaccharomyces pombe. Yukawa M, et al. G3 (Bethesda), 2019 Jan 9. PMID 30463883, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. spindle anchoring through Msd1-Wdr8-Pkl1 is crucial for balancing the Cut7/kinesin-5-mediated outward force at the spindle pole body.
      Title: The Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables spindle pole body anchor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule anchoring at mitotic spindle pole body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MWP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microtubule-anchoring factor Msd1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3050551..3051959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022181.3 → NP_596261.1  microtubule-anchoring factor Msd1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P6R4
      Conserved Domains (1) summary
      pfam11559
      Location:14 → 161
      ADIP; Afadin- and alpha -actinin-Binding
    Nucleotide Protein
    Heading Accession and Version

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