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    VTC5 Vtc5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851663, updated on 2-Nov-2024

    Summary

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    Official Symbol
    VTC5
    Official Full Name
    Vtc5p
    Primary source
    SGD:S000002496
    Locus tag
    YDR089W
    See related
    AllianceGenome:SGD:S000002496; FungiDB:YDR089W; VEuPathDB:YDR089W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in intracellular phosphate ion homeostasis and polyphosphate biosynthetic process. Located in fungal-type vacuole membrane. Part of vacuolar transporter chaperone complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See VTC5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (622112..624721)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mRNA splicing protein SLU7 Neighboring gene tRNA-Arg Neighboring gene Ilt1p Neighboring gene Fe-S cluster-binding ribosome biosynthesis protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenotypic heterogeneity can enhance rare-cell survival in 'stress-sensitive' yeast populations. Bishop AL, et al. Mol Microbiol, 2007 Jan. PMID 17176259
    2. Vtc5 Is Localized to the Vacuole Membrane by the Conserved AP-3 Complex to Regulate Polyphosphate Synthesis in Budding Yeast. Bentley-DeSousa A, et al. mBio, 2021 Oct 26. PMID 34544285, Free PMC Article
    3. A novel family of yeast chaperons involved in the distribution of V-ATPase and other membrane proteins. Cohen A, et al. J Biol Chem, 1999 Sep 17. PMID 10480897
    4. Vtc5, a Novel Subunit of the Vacuolar Transporter Chaperone Complex, Regulates Polyphosphate Synthesis and Phosphate Homeostasis in Yeast. Desfougères Y, et al. J Biol Chem, 2016 Oct 14. PMID 27587415, Free PMC Article
    5. Overexpression of polyphosphate polymerases and deletion of polyphosphate phosphatases shorten the replicative lifespan in yeast. Umeda C, et al. FEBS Lett, 2023 Sep. PMID 37574219

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular phosphate ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar transporter chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar transporter chaperone complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar transporter chaperone complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vtc5p
    NP_010374.1
    • Novel subunit of the vacuolar transporter chaperone complex; vacuolar transmembrane protein that regulates biosynthesis of polyphosphate; deletion reduces and overexpression increases polyP accumulation; SPX domain (Syg1, Pho81, Xpr1)-containing protein involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      622112..624721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180397.1 → NP_010374.1  TPA: Vtc5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010374.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS76, P38966, Q03192
      UniProtKB/TrEMBL
      A6ZY55, C7GVP7
      Conserved Domains (1) summary
      cd14474
      Location:2 → 142
      SPX_YDR089W; SPX domain of the yeast protein YDR089W and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38966.2

    Gene LinkOut

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