U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SAM50 SAM complex subunit SAM50 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855705, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SAM50
    Official Full Name
    SAM complex subunit SAM50
    Primary source
    SGD:S000004971
    Locus tag
    YNL026W
    See related
    AllianceGenome:SGD:S000004971; FungiDB:YNL026W; VEuPathDB:YNL026W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    OMP85; TOB55
    Summary
    Enables protein transmembrane transporter activity. Involved in protein insertion into mitochondrial outer membrane and protein-containing complex assembly. Located in mitochondrial outer membrane. Part of SAM complex. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to human SAMM50 (SAMM50 sorting and assembly machinery component). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SAM50 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (581920..583374)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative mannosyltransferase Neighboring gene DNA-binding transcription factor CRZ1 Neighboring gene cyclin-dependent protein serine/threonine kinase regulator SSN8 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evolutionary conservation of biogenesis of beta-barrel membrane proteins. Paschen SA, et al. Nature, 2003 Dec 18. PMID 14685243
    2. The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria. Gentle I, et al. J Cell Biol, 2004 Jan 5. PMID 14699090, Free PMC Article
    3. Signals in bacterial beta-barrel proteins are functional in eukaryotic cells for targeting to and assembly in mitochondria. Walther DM, et al. Proc Natl Acad Sci U S A, 2009 Feb 24. PMID 19181862, Free PMC Article
    4. The N-terminal domain of Tob55 has a receptor-like function in the biogenesis of mitochondrial beta-barrel proteins. Habib SJ, et al. J Cell Biol, 2007 Jan 1. PMID 17190789, Free PMC Article
    5. Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability. Milenkovic D, et al. J Biol Chem, 2004 May 21. PMID 15067005

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the polypeptide transport-associated domain of Sam50 is not essential for recognition of beta-barrel precursors but instead promotes the release of precursor proteins from the SAM complex
      Title: Biogenesis of mitochondrial β-barrel proteins: the POTRA domain is involved in precursor release from the SAM complex.
    2. Assembly of newly synthesized Tob55 into preexisting TOB complexes depended on Tob38 but did not require Mas37
      Title: Assembly of the TOB complex of mitochondria.
    3. These results demonstrate that the N-terminal domain of Tob55 recognizes precursors of beta-barrel proteins.
      Title: The N-terminal domain of Tob55 has a receptor-like function in the biogenesis of mitochondrial beta-barrel proteins.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    SAM complex subunit SAM50
    NP_014372.1
    • Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      581920..583374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182865.1 → NP_014372.1  TPA: SAM complex subunit SAM50 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014372.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1F2, P53969
      UniProtKB/TrEMBL
      A6ZS53, B5VR11, C7GWP4, E9P977, G2WM78, N1NWQ0
      Conserved Domains (1) summary
      COG4775
      Location:1 → 483
      BamA; Outer membrane protein assembly factor BamA [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53969.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools