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    GAD1 glutamate decarboxylase GAD1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855291, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GAD1
    Official Full Name
    glutamate decarboxylase GAD1
    Primary source
    SGD:S000004862
    Locus tag
    YMR250W
    See related
    AllianceGenome:SGD:S000004862; FungiDB:YMR250W; VEuPathDB:YMR250W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glutamate decarboxylase activity. Involved in cellular response to oxidative stress and glutamate catabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GAD1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (770801..772558)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene tRNA-Ala Neighboring gene uncharacterized protein Neighboring gene omega-class glutathione transferase Neighboring gene Hor7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae. Kamei Y, et al. Biochem Biophys Res Commun, 2011 Apr 1. PMID 21371425
    2. GABA shunt mediates thermotolerance in Saccharomyces cerevisiae by reducing reactive oxygen production. Cao J, et al. Yeast, 2013 Apr. PMID 23447388
    3. New insights into {gamma}-aminobutyric acid catabolism: Evidence for {gamma}-hydroxybutyric acid and polyhydroxybutyrate synthesis in Saccharomyces cerevisiae. Bach B, et al. Appl Environ Microbiol, 2009 Jul. PMID 19411412, Free PMC Article
    4. Alanine Represses γ-Aminobutyric Acid Utilization and Induces Alanine Transaminase Required for Mitochondrial Function in Saccharomyces cerevisiae. Márquez D, et al. Front Microbiol, 2021. PMID 34421848, Free PMC Article
    5. Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. Coleman ST, et al. J Biol Chem, 2001 Jan 5. PMID 11031268

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GAD1, UGA1 and UGA2 mediates thermotolerance by reducing reactive oxygen production.
      Title: GABA shunt mediates thermotolerance in Saccharomyces cerevisiae by reducing reactive oxygen production.
    2. UGA1 and GAD1 were identified as aging genes.
      Title: GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate decarboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutamate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutamate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutamate decarboxylase GAD1
    NP_013976.1
    • Glutamate decarboxylase; converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      770801..772558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182756.1 → NP_013976.1  TPA: glutamate decarboxylase GAD1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013976.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W076, Q04792
      UniProtKB/TrEMBL
      A6ZMW5, B3LMD8, B5VQ18, C7GRA2, C8ZFB5, D0VFN3, G2WKV8
      Conserved Domains (1) summary
      TIGR01788
      Location:41 → 522
      Glu-decarb-GAD; glutamate decarboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04792.1

    Gene LinkOut

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