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    ABZ1 4-amino-4-deoxychorismate synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855768, updated on 17-May-2024

    Summary

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    Gene symbol
    ABZ1
    Gene description
    4-amino-4-deoxychorismate synthase
    Primary source
    FungiDB:YNR033W
    Locus tag
    YNR033W
    See related
    SGD:S000005316; AllianceGenome:SGD:S000005316; VEuPathDB:YNR033W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 4-amino-4-deoxychorismate synthase activity. Involved in para-aminobenzoic acid biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ABZ1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (687635..689998)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative serine/threonine-protein kinase PPG1 Neighboring gene ubiquitin-like protein HUB1 Neighboring gene Sol1p Neighboring gene Ego4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. para-Aminobenzoic acid is a precursor in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae. Marbois B, et al. J Biol Chem, 2010 Sep 3. PMID 20592037, Free PMC Article
    2. Sulfa drug screening in yeast: fifteen sulfa drugs compete with p-aminobenzoate in Saccharomyces cerevisiae. Castelli LA, et al. FEMS Microbiol Lett, 2001 May 30. PMID 11377864
    3. Para-aminobenzoate synthase gene of Saccharomyces cerevisiae encodes a bifunctional enzyme. Edman JC, et al. Yeast, 1993 Jun. PMID 8346682
    4. QTL mapping of the production of wine aroma compounds by yeast. Steyer D, et al. BMC Genomics, 2012 Oct 30. PMID 23110365, Free PMC Article
    5. Mechanism of high folate accumulation in a sake yeast other than Kyokai yeasts. Shibata Y, et al. J Biosci Bioeng, 2020 Jan. PMID 31515157

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4-amino-4-deoxychorismate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-amino-4-deoxychorismate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-amino-4-deoxychorismate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 4-amino-4-deoxychorismate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in folic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in para-aminobenzoic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in para-aminobenzoic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    4-amino-4-deoxychorismate synthase
    NP_014431.1
    • Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      687635..689998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183210.1 → NP_014431.1  TPA: 4-amino-4-deoxychorismate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014431.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1K8, P37254, Q02982, Q6B1Q1
      UniProtKB/TrEMBL
      A0A8H4F807, N1NWU0
      Conserved Domains (1) summary
      TIGR01823
      Location:10 → 787
      PabB-fungal; aminodeoxychorismate synthase, fungal clade
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37254.4

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