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    kin1 MARK/PAR-1 kinase Kin1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540792, updated on 18-Sep-2024

    Summary

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    Official Symbol
    kin1
    Official Full Name
    MARK/PAR-1 kinase Kin1
    Primary source
    PomBase:SPBC4F6.06
    Locus tag
    SPOM_SPBC4F6.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See kin1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2694332..2698128)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene lectin family glycoprotein receptor Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Mak5 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The protein kinase kin1 is required for cellular symmetry in fission yeast. La Carbona S, et al. Biol Cell, 2004 Mar. PMID 15050371
    2. A putative protein kinase gene (kin1+) is important for growth polarity in Schizosaccharomyces pombe. Levin DE, et al. Proc Natl Acad Sci U S A, 1990 Nov. PMID 2236039, Free PMC Article
    3. The protein kinase kin1, the fission yeast orthologue of mammalian MARK/PAR-1, localises to new cell ends after mitosis and is important for bipolar growth. Drewes G, et al. FEBS Lett, 2003 Nov 6. PMID 14596912
    4. Spatial regulation of cytokinesis by the Kin1 and Pom1 kinases in fission yeast. La Carbona S, et al. Curr Genet, 2006 Dec. PMID 16988828
    5. Role of the protein kinase Kin1 and nuclear centering in actomyosin ring formation in fission yeast. Cadou A, et al. Cell Cycle, 2009 Aug. PMID 19597328, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ssp1 promotes cell polarity by phosphorylating the activation loop of the MARK/PAR-1 family kinase Kin1. Additional Kin1 substrates for cell polarity and cytokinesis were also phosphorylated by the DYRK family member Pom1.
      Title: Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division.
    2. The authors propose that Kin1 is required for a tight link between the plasma membrane and the cell wall.
      Title: Kin1 is a plasma membrane-associated kinase that regulates the cell surface in fission yeast.
    3. nuclear centering becomes essential when Pom1/Tea1/Tea4 function is compromised and that Kin1 expression level is a key regulatory element in this situation
      Title: Role of the protein kinase Kin1 and nuclear centering in actomyosin ring formation in fission yeast.
    4. Kin1 is required for F-actin polarization in interphase and after completion of mitosis and this function may be essential for cytokinesis in a pom1Delta background.
      Title: Spatial regulation of cytokinesis by the Kin1 and Pom1 kinases in fission yeast.
    5. The protein kinase kin1 is encoded by a non essential gene and affects polarised cell growth.
      Title: An overview of the KIN1/PAR-1/MARK kinase family.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell growth mode switching, monopolar to bipolar IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of actin cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis, division site positioning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cytokinesis, division site positioning EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex of cell tip EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in medial cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in new growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in non-growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in old cell tip after activation of bipolar cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MARK/PAR-1 kinase Kin1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2694332..2698128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022023.3 → NP_596106.1  MARK/PAR-1 kinase Kin1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596106.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74392, P22987
      Conserved Domains (3) summary
      cd12121
      Location:753 → 889
      MARK_C_like; C-terminal kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases, and similar domains
      smart00220
      Location:125 → 395
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14077
      Location:123 → 395
      STKc_Kin1_2; Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version

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