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    SYO1 Syo1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851497, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SYO1
    Official Full Name
    Syo1p
    Primary source
    SGD:S000002221
    Locus tag
    YDL063C
    See related
    AllianceGenome:SGD:S000002221; FungiDB:YDL063C; VEuPathDB:YDL063C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables unfolded protein binding activity. Involved in protein import into nucleus and ribosomal large subunit biogenesis. Located in cytoplasm and nucleus. Used to study Diamond-Blackfan anemia. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia. Orthologous to human HEATR3 (HEAT repeat containing 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SYO1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (338272..340134, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pex19p Neighboring gene E2 SUMO-conjugating protein UBC9 Neighboring gene ribosomal 40S subunit protein S29B Neighboring gene Tsr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamics of ribosome scanning and recycling revealed by translation complex profiling. Archer SK, et al. Nature, 2016 Jul 28. PMID 27437580
    2. Synchronizing nuclear import of ribosomal proteins with ribosome assembly. Kressler D, et al. Science, 2012 Nov 2. PMID 23118189
    3. Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones. Pausch P, et al. Nat Commun, 2015 Jun 26. PMID 26112308, Free PMC Article
    4. The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes. Wade CH, et al. Yeast, 2006 Mar. PMID 16544271
    5. Translation initiation factor eIF4G1 modulates assembly of the polypeptide exit tunnel region in yeast ribosome biogenesis. Tseng YT, et al. J Cell Sci, 2022 Jun 15. PMID 35615984

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Syo1p
    NP_010220.1
    • Transport adaptor or symportin; assembly chaperone that co-translationally associates with nascent Rpl5p, preventing aggregation; facilitates synchronized nuclear coimport of two 5S-rRNA binding proteins, Rpl5p and Rpl11p, mediated by import receptor Kap104p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      338272..340134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180122.1 → NP_010220.1  TPA: Syo1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010220.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRT4, P89893, Q07395, Q7LGT0
      UniProtKB/TrEMBL
      A6ZXR3, B3LGW0, C7GJP6, C8Z4K6, N1PAA1
      Conserved Domains (1) summary
      cd13394
      Location:15 → 615
      Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07395.1

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