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    PFK27 6-phosphofructo-2-kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853984, updated on 17-May-2024

    Summary

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    Gene symbol
    PFK27
    Gene description
    6-phosphofructo-2-kinase
    Primary source
    FungiDB:YOL136C
    Locus tag
    YOL136C
    See related
    SGD:S000005496; AllianceGenome:SGD:S000005496; VEuPathDB:YOL136C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Involved in fructose 2,6-bisphosphate metabolic process and regulation of glycolytic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PFK27 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (67561..68754, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rtc1p Neighboring gene Bsc6p Neighboring gene mediator complex subunit MED7 Neighboring gene SCF ubiquitin ligase complex subunit HRT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of a second gene encoding 5-phosphofructo-2-kinase in yeast, and characterization of mutant strains without fructose-2,6-bisphosphate. Boles E, et al. Mol Microbiol, 1996 Apr. PMID 8861205
    2. One-step purification of recombinant yeast 6-phosphofructo-2-kinase after the identification of contaminants by MALDI-TOF MS. Dihazi H, et al. Protein Expr Purif, 2001 Feb. PMID 11162407
    3. Signalling pathways leading to transcriptional regulation of genes involved in the activation of glycolysis in yeast. Gonçalves PM, et al. Mol Microbiol, 1997 Aug. PMID 9302011
    4. Sequence analysis of a 12 801 bp fragment of the left arm of yeast chromosome XV containing a putative 6-phosphofructo-2-kinase gene, a gene for a possible glycophospholipid-anchored surface protein and six other open reading frames. Aldea M, et al. Yeast, 1996 Sep. PMID 8896270
    5. Mutation of monofunctional 6-phosphofructo-2-kinase in yeast to bifunctional 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase. Kretschmer M, et al. Biochemistry, 1993 Oct 19. PMID 8218176

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pfk27 is a metabolic targets of Skp1-Cul1-F-box (SCF) ubiquitin ligase.
      Title: A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 6-phosphofructo-2-kinase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    6-phosphofructo-2-kinase
    NP_014505.1
    • 6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      67561..68754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183390.1 → NP_014505.1  TPA: 6-phosphofructo-2-kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014505.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1T3, Q12471
      UniProtKB/TrEMBL
      A0A8H4BUQ2, A6ZN76, B3LIT1, B5VRC5, C7GV11, C8ZHI1, G2WMA2, N1NWZ7
      Conserved Domains (1) summary
      pfam01591
      Location:84 → 324
      6PF2K; 6-phosphofructo-2-kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12471.1

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