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    OTU1 ubiquitin-specific protease OTU1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850500, updated on 18-Sep-2024

    Summary

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    Official Symbol
    OTU1
    Official Full Name
    ubiquitin-specific protease OTU1
    Primary source
    SGD:S000001850
    Locus tag
    YFL044C
    See related
    AllianceGenome:SGD:S000001850; FungiDB:YFL044C; VEuPathDB:YFL044C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables thiol-dependent deubiquitinase. Involved in protein deubiquitination and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Orthologous to human YOD1 (YOD1 deubiquitinase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See OTU1 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (44655..45560, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Fmp32p Neighboring gene phosphomannomutase SEC53 Neighboring gene Lam5p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray crystallographic analysis of the complex between the N-D1 domain of VCP from Homo sapiens and the N domain of OTU1 from Saccharomyces cerevisiae. Kim SJ, et al. Acta Crystallogr F Struct Biol Commun, 2014 Aug. PMID 25084388, Free PMC Article
    2. Structural basis for ovarian tumor domain-containing protein 1 (OTU1) binding to p97/valosin-containing protein (VCP). Kim SJ, et al. J Biol Chem, 2014 May 2. PMID 24610782, Free PMC Article
    3. Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex. Bodnar NO, et al. Cell, 2017 May 4. PMID 28475898, Free PMC Article
    4. Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain protein. Messick TE, et al. J Biol Chem, 2008 Apr 18. PMID 18270205, Free PMC Article
    5. Genomic analysis of PIS1 gene expression. Gardocki ME, et al. Eukaryot Cell, 2005 Mar. PMID 15755922, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that 39GYPP42 (S3/S4) loop of yeast OTU1 is critical for interaction with human p97/valosin-containing protein (VCP).
      Title: Structural basis for ovarian tumor domain-containing protein 1 (OTU1) binding to p97/valosin-containing protein (VCP).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-specific protease OTU1
    NP_116610.1
    • Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      44655..45560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179923.1 → NP_116610.1  TPA: ubiquitin-specific protease OTU1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116610.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTI6, P43558
      UniProtKB/TrEMBL
      A7A1Z5, B3LUG7, B5VHY3, C8Z7N8, N1P319
      Conserved Domains (1) summary
      COG5539
      Location:1 → 300
      COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43558.1

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