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    SLC1 1-acylglycerol-3-phosphate O-acyltransferase SLC1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851508, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SLC1
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase SLC1
    Primary source
    SGD:S000002210
    Locus tag
    YDL052C
    See related
    AllianceGenome:SGD:S000002210; FungiDB:YDL052C; VEuPathDB:YDL052C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in glycerophospholipid biosynthetic process. Located in lipid droplet. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to human AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1) and AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SLC1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (362672..363583, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mch1p Neighboring gene Pbp4p Neighboring gene Lhp1p Neighboring gene Knh1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Changes in oil content of transgenic soybeans expressing the yeast SLC1 gene. Rao SS, et al. Lipids, 2009 Oct. PMID 19768478
    2. Modification of seed oil content and acyl composition in the brassicaceae by expression of a yeast sn-2 acyltransferase gene. Zou J, et al. Plant Cell, 1997 Jun. PMID 9212466, Free PMC Article
    3. Possible Role of Different Yeast and Plant Lysophospholipid:Acyl-CoA Acyltransferases (LPLATs) in Acyl Remodelling of Phospholipids. Jasieniecka-Gazarkiewicz K, et al. Lipids, 2016 Jan. PMID 26643989, Free PMC Article
    4. Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay. Shui G, et al. PLoS One, 2010 Aug 4. PMID 20694142, Free PMC Article
    5. A family of eukaryotic lysophospholipid acyltransferases with broad specificity. Ståhl U, et al. FEBS Lett, 2008 Jan 23. PMID 18154737

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Saccharomyces cerevisiae Delta9-desaturase Ole1 forms a supercomplex with Slc1 and Dga1.
      Title: Saccharomyces cerevisiae Δ9-desaturase Ole1 forms a supercomplex with Slc1 and Dga1.
    2. pology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae.
      Title: Topology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae.
    3. Transgenic soybean somatic embryos expressing yeast SLC1 gene show an increase in triacylglycerol content.
      Title: Changes in oil content of transgenic soybeans expressing the yeast SLC1 gene.
    4. in concert with Slc1, Lpt1 plays a central role in Phosphatidic acid biosynthesis, which is essential for cell viability.
      Title: LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae.
    5. Lpt1p, a member of the membrane-bound o-acyltransferase gene family, seems to work in conjunction with Slc1 to mediate the incorporation of unsaturated acyl chains into the sn-2 position of phospholipids.
      Title: Identification of a novel lysophospholipid acyltransferase in Saccharomyces cerevisiae.
    6. Slc1p and Slc4p may not only be active as 1-acylglycerol-3-phosphate O-acyltransferases but also be involved in fatty acid exchange at the sn-2-position of mature glycerophospholipids.
      Title: SLC1 and SLC4 encode partially redundant acyl-coenzyme A 1-acylglycerol-3-phosphate O-acyltransferases of budding yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-acylglycerophosphocholine O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerophospholipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-acylglycerol-3-phosphate O-acyltransferase SLC1
    NP_010231.1
    • 1-acyl-sn-glycerol-3-phosphate acyltransferase; catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      362672..363583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180111.1 → NP_010231.1  TPA: 1-acylglycerol-3-phosphate O-acyltransferase SLC1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010231.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRU4, E9P8Y5, P33333
      UniProtKB/TrEMBL
      C7GW89, C8Z4L7, G2WCA8, I6Y6X1, N1P7S3
      Conserved Domains (1) summary
      TIGR00530
      Location:60 → 191
      AGP_acyltrn; 1-acyl-sn-glycerol-3-phosphate acyltransferases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33333.1

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