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    DPB4 DNA polymerase epsilon noncatalytic subunit [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851699, updated on 19-Jun-2024

    Summary

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    Gene symbol
    DPB4
    Gene description
    DNA polymerase epsilon noncatalytic subunit
    Primary source
    FungiDB:YDR121W
    Locus tag
    YDR121W
    See related
    SGD:S000002528; AllianceGenome:SGD:S000002528; VEuPathDB:YDR121W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables nucleosomal DNA binding activity. Contributes to DNA binding activity; DNA polymerase processivity factor activity; and single-stranded DNA 3'-5' exodeoxyribonuclease activity. Involved in error-prone translesion synthesis; leading strand elongation; and nucleosome mobilization. Part of CHRAC and epsilon DNA polymerase complex. Orthologous to human POLE3 (DNA polymerase epsilon 3, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DPB4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (693585..694175)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cox26p Neighboring gene tRNA (guanine26-N2)-dimethyltransferase Neighboring gene serine/threonine protein kinase KIN1 Neighboring gene Ino2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conformational changes associated with template commitment in ATP-dependent chromatin remodeling by ISW2. Gangaraju VK, et al. Mol Cell, 2009 Jul 10. PMID 19595716, Free PMC Article
    2. The Dpb4 subunit of ISW2 is anchored to extranucleosomal DNA. Dang W, et al. J Biol Chem, 2007 Jul 6. PMID 17491017
    3. Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes. Casari E, et al. Nat Commun, 2021 Aug 6. PMID 34362907, Free PMC Article
    4. Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome. Yuan Z, et al. Nat Commun, 2020 Jun 22. PMID 32572031, Free PMC Article
    5. Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ϵ. Ter Beek J, et al. Nucleic Acids Res, 2019 Jun 20. PMID 30968138, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to DNA polymerase processivity factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA polymerase processivity factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleosomal DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to single-stranded DNA 3'-5' DNA exonuclease activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in error-prone translesion synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leading strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leading strand elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in leading strand elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA double-strand break processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CHRAC IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CHRAC IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CHRAC IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of epsilon DNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of epsilon DNA polymerase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase epsilon noncatalytic subunit
    NP_010406.3
    • Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      693585..694175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180429.3 → NP_010406.3  TPA: DNA polymerase epsilon noncatalytic subunit [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010406.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSA7, Q04603
      UniProtKB/TrEMBL
      A0A8H8UN35, B3LGF5, B5VG16, C7GIM9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    6WJV_4.1
    Q04603.1

    Gene LinkOut

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