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    pgr1 glutathione reductase Pgr1;mitochondrial glutathione reductase Pgr1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540156, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pgr1
    Official Full Name
    glutathione reductase Pgr1;mitochondrial glutathione reductase Pgr1
    Primary source
    PomBase:SPBC17A3.07
    Locus tag
    SPOM_SPBC17A3.07
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pgr1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (1414440..1416156)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene J domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene phosphoprotein phosphatase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene deoxyribonuclease Tat-D Neighboring gene lipoate-protein ligase A Neighboring gene peroxin pas4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of decreased specific glutathione reductase activity in a chromate-tolerant mutant of Schizosaccharomyces pombe. Koósz Z, et al. Folia Microbiol (Praha), 2008. PMID 18759114
    2. Isolation, expression, and regulation of the pgr1(+) gene encoding glutathione reductase absolutely required for the growth of Schizosaccharomyces pombe. Lee J, et al. J Biol Chem, 1997 Sep 12. PMID 9287302
    3. Glutathione reductase and a mitochondrial thioredoxin play overlapping roles in maintaining iron-sulfur enzymes in fission yeast. Song JY, et al. Eukaryot Cell, 2006 Nov. PMID 16950927, Free PMC Article
    4. Systematic analysis reveals the prevalence and principles of bypassable gene essentiality. Li J, et al. Nat Commun, 2019 Mar 1. PMID 30824696, Free PMC Article
    5. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glutathione reductase activity is essential for chromate tolerance.
      Title: Effects of decreased specific glutathione reductase activity in a chromate-tolerant mutant of Schizosaccharomyces pombe.
    2. These results indicate that glutathione reductase is essential in the aerobic growth of S. pombe due to its role in maintaining oxidation-labile Fe-S enzymes and iron homeostasis through mitochondrial thioredoxin Trx2.
      Title: Glutathione reductase and a mitochondrial thioredoxin play overlapping roles in maintaining iron-sulfur enzymes in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione-disulfide reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione-disulfide reductase (NADPH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular oxidant detoxification IC
    Inferred by Curator
    more info
    		 PubMed 
    NOT involved_in cellular response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to menadione IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione reductase Pgr1;mitochondrial glutathione reductase Pgr1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1414440..1416156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021485.2 → NP_595589.1  glutathione reductase Pgr1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595589.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13631, P78965
      Conserved Domains (4) summary
      PRK06116
      Location:5 → 463
      PRK06116; glutathione reductase; Validated
      pfam00070
      Location:180 → 256
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:352 → 462
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
      cl21454
      Location:20 → 209
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001431021.1 → NP_001417930.1  mitochondrial glutathione reductase Pgr1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13631, P78965
    Nucleotide Protein
    Heading Accession and Version

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