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    CPS1 Gly-Xaa carboxypeptidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853267, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CPS1
    Official Full Name
    Gly-Xaa carboxypeptidase
    Primary source
    SGD:S000003708
    Locus tag
    YJL172W
    See related
    AllianceGenome:SGD:S000003708; FungiDB:YJL172W; VEuPathDB:YJL172W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables carboxypeptidase activity. Involved in proteolysis involved in protein catabolic process. Located in fungal-type vacuole lumen. Orthologous to human PM20D1 (peptidase M20 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CPS1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (97737..99467)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Kre9p Neighboring gene Rfa3p Neighboring gene Toh1p Neighboring gene Asg7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and sequencing of genomic DNA encoding yeast vacuolar carboxypeptidase yscS. Bordallo J, et al. FEBS Lett, 1991 May 20. PMID 1709881
    2. Carboxypeptidase yscS: gene structure and function of the vacuolar enzyme. Spormann DO, et al. Eur J Biochem, 1991 Apr 23. PMID 2026161
    3. Control of Saccharomyces cerevisiae carboxypeptidase S (CPS1) gene expression under nutrient limitation. Bordallo J, et al. Yeast, 1993 Apr. PMID 8511964
    4. Cis and trans-acting regulatory elements required for regulation of the CPS1 gene in Saccharomyces cerevisiae. Bordallo J, et al. Mol Gen Genet, 1995 Mar 10. PMID 7700231
    5. Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Odorizzi G, et al. Cell, 1998 Dec 11. PMID 9865702

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxypeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    is_active_in fungal-type vacuole lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gly-Xaa carboxypeptidase
    NP_012363.1
    • Vacuolar carboxypeptidase S; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via AP-3 pathway; expression induced under low-nitrogen conditions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      97737..99467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181605.1 → NP_012363.1  TPA: Gly-Xaa carboxypeptidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW16, P27614
      UniProtKB/TrEMBL
      B3LPV2, C8ZB47
      Conserved Domains (1) summary
      cd05674
      Location:91 → 570
      M20_yscS; M20 Peptidase, carboxypeptidase yscS
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27614.2

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