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    cyp1 cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543019, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cyp1
    Official Full Name
    cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp1
    Primary source
    PomBase:SPAC57A10.03
    Locus tag
    SPOM_SPAC57A10.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cyp1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003424.3 (1368160..1369574)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase Cdr2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Rho guanine nucleotide exchange factor Neighboring gene SAGA complex deubiquitinating submodule subunit Sgf11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyclophilins of a novel subfamily interact with SNW/SKIP coregulator in Dictyostelium discoideum and Schizosaccharomyces pombe. Skruzný M, et al. Biochim Biophys Acta, 2001 Oct 31. PMID 11690648
    2. Cyclophilin sensitivity to sanglifehrin A can be correlated to the same specific tryptophan residue as cyclosporin A. Pemberton TJ, et al. FEBS Lett, 2003 Dec 4. PMID 14644438
    3. Structure of a yeast spliceosome at 3.6-angstrom resolution. Yan C, et al. Science, 2015 Sep 11. PMID 26292707
    4. Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10. Livesay SB, et al. Eukaryot Cell, 2013 Nov. PMID 24014766, Free PMC Article
    5. The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast. Kallgren SP, et al. PLoS Genet, 2014. PMID 24874881, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    part_of post-mRNA release spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1368160..1369574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018738.3 → NP_593308.1  cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593308.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P87051
      Conserved Domains (1) summary
      cl00197
      Location:6 → 151
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
    Nucleotide Protein
    Heading Accession and Version

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