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    RET1 DNA-directed RNA polymerase III core subunit RET1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854382, updated on 28-Oct-2024

    Summary

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    Official Symbol
    RET1
    Official Full Name
    DNA-directed RNA polymerase III core subunit RET1
    Primary source
    SGD:S000005733
    Locus tag
    YOR207C
    See related
    AllianceGenome:SGD:S000005733; FungiDB:YOR207C; VEuPathDB:YOR207C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PDS2; RPC128; RPC2
    Summary
    Contributes to RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III. Part of RNA polymerase III complex. Used to study hypomyelinating leukodystrophy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and hypomyelinating leukodystrophy 8. Orthologous to human POLR3B (RNA polymerase III subunit B). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See RET1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (730008..733457, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Gep3p Neighboring gene mRNA-binding ribosome synthesis protein NOC2 Neighboring gene tyrosine protein phosphatase PTP2 Neighboring gene nicotinate phosphoribosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RET1 gene of yeast encodes the second-largest subunit of RNA polymerase III. Structural analysis of the wild-type and ret1-1 mutant alleles. James P, et al. J Biol Chem, 1991 Mar 25. PMID 2005101
    2. ret1-1, a yeast mutant affecting transcription termination by RNA polymerase III. James P, et al. Genetics, 1990 Jun. PMID 2199311, Free PMC Article
    3. Termination-altering mutations in the second-largest subunit of yeast RNA polymerase III. Shaaban SA, et al. Mol Cell Biol, 1995 Mar. PMID 7862140, Free PMC Article
    4. In vitro analysis of elongation and termination by mutant RNA polymerases with altered termination behavior. Shaaban SA, et al. Mol Cell Biol, 1996 Nov. PMID 8887675, Free PMC Article
    5. Coordinated nuclear import of RNA polymerase III subunits. Hardeland U, et al. Traffic, 2006 Apr. PMID 16536744

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast Bud27 modulates the biogenesis of Rpc128 and Rpc160 subunits and the assembly of RNA polymerase III.
      Title: Yeast Bud27 modulates the biogenesis of Rpc128 and Rpc160 subunits and the assembly of RNA polymerase III.
    2. the properties of the corresponding RNAPII (Rpb2-832GYNQED837) and RNAPIII (Rpc128-764GYDIED769) loops by a local mutagenesis of their invariant carboxyl acids.
      Title: Crucial role of a dicarboxylic motif in the catalytic center of yeast RNA polymerases.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA transcription by RNA polymerase III IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III core subunit RET1
    NP_014850.1
    • Second-largest subunit of RNA polymerase III; RNA polymerase III is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      730008..733457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183626.1 → NP_014850.1  TPA: DNA-directed RNA polymerase III core subunit RET1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014850.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2R3, P22276, Q12696
      UniProtKB/TrEMBL
      A6ZP50, C7GWH5, C8ZGW3, G2WN79, N1NX57
      Conserved Domains (1) summary
      COG0085
      Location:26 → 1147
      RpoB; DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22276.2

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