sty1 MAP kinase Sty1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Gene symbol: sty1
Gene description: MAP kinase Sty1
Locus tag: SPOM_SPAC24B11.06C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: phh1; spc1
Old locus tag: SPAC24B11.06c
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Genomic context

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See sty1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (206476..208136, complement)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of the Transcription Factor Atf1 at Multiple Sites by the MAP Kinase Sty1 Controls Homologous Recombination and Transcription.
Title: Phosphorylation of the Transcription Factor Atf1 at Multiple Sites by the MAP Kinase Sty1 Controls Homologous Recombination and Transcription.
propose that the gas1-287 mutation causes longevity as the similar mechanism as cell wall stress depending on Pmk1 and Sty1 MAPK pathways
Title: gas1 mutation extends chronological lifespan via Pmk1 and Sty1 MAPKs in Schizosaccharomyces pombe.
Sty1 and Atf1 were involved in regulating mitotic slowdown in Schizosaccharomyces pombe under nitrosative stress.
Title: Transcription factors Atf1 and Sty1 promote stress tolerance under nitrosative stress in Schizosaccharomyces pombe.
The fission yeast stress-activated protein kinase Sty1, a homolog of mammalian p38 MAP kinase, regulates localization of the Cdc42 polarity module.
Title: Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway.
Data suggest that osmotic stress induces hyperphosphorylation of mitotic inducer cdr1 for several hours and cells delay division during same time period; this stress-induced hyperphosphorylation requires both cdr1 autophosphorylation and stress-activated protein kinase sty1. (cdr1 = serine/threonine protein kinase cdr1/nim1; sty1 = MAP kinase sty1)
Title: Dynamic regulation of Cdr1 kinase localization and phosphorylation during osmotic stress.
Data suggest that S. pombe 972 expressing a nonphosphorylatable Atf1 variant is more sensitive to oxidative stress because of impaired transcription of subset of stress genes whose expression is controlled by Pap1; in S. pombe 972 expressing phospho-mimicking Atf1 mutant, presence of Sty1 is completely dispensable. (Atf1 = transcription factor Atf1; Sty1 = MAP kinase Sty1; Pap1 = transcription factor Pap1)
Title: Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.
Threonine-monophosphorylated Sty1 displays a limited biological activity particularly at the transcriptional level.
Title: Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast.
Data suggests that Sty1 activation promotes Pyp2 phosphorylation to increase the stability of the phosphatase. This MAPK-dependent Pyp2 stabilisation allows cells to attenuate MAPK signalling and resume cell division, once stresses have been dealt with.
Title: Control of Sty1 MAPK activity through stabilisation of the Pyp2 MAPK phosphatase.
Sty1 and PKA activity in stationary phase is essential for interaction between Sds23/Psp1/Moc1 and Ufd2.
Title: Phosphorylations of Sds23/Psp1/Moc1 by stress-activated kinase and cAMP-dependent kinase are essential for regulating cell viability in prolonged stationary phase.
Data indicate that MAPKKK heteromer promotes stress signaling to the Spc1 MAPK.
Title: Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables ATP binding	ISM Inferred from Sequence Model more info
enables MAP kinase activity	EXP Inferred from Experiment more info	PubMed
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G2/M transition of mitotic cell cycle	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of cytoplasmic translational initiation in response to stress	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of induction of conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osmosensory signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of silent mating-type cassette heterochromatin formation	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic actomyosin contractile ring assembly	EXP Inferred from Experiment more info	PubMed
involved_in regulation of reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	EXP Inferred from Experiment more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic stress granule	EXP Inferred from Experiment more info	PubMed
is_active_in cytosol	HDA more info	PubMed
is_active_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	EXP Inferred from Experiment more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MAP kinase Sty1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

206476..208136 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001018244.3 → NP_592843.1 MAP kinase Sty1 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_592843.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q09892

Conserved Domains (2) summary

smart00220
Location:20 → 299

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07856
Location:9 → 336

STKc_Sty1_Hog1; Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1