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    MIP6 Mip6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856408, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MIP6
    Official Full Name
    Mip6p
    Primary source
    SGD:S000001057
    Locus tag
    YHR015W
    See related
    AllianceGenome:SGD:S000001057; FungiDB:YHR015W; VEuPathDB:YHR015W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Involved in mRNA localization resulting in posttranscriptional regulation of gene expression; mRNA metabolic process; and regulation of translation. Located in prospore membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MIP6 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (134554..136533)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene tRNA-Gln Neighboring gene Ysc84p Neighboring gene Ysc83p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A multi-omics dataset of heat-shock response in the yeast RNA binding protein Mip6. Nuño-Cabanes C, et al. Sci Data, 2020 Feb 27. PMID 32109230, Free PMC Article
    2. Predicted RNA Binding Proteins Pes4 and Mip6 Regulate mRNA Levels, Translation, and Localization during Sporulation in Budding Yeast. Jin L, et al. Mol Cell Biol, 2017 May 1. PMID 28193845, Free PMC Article
    3. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. Segref A, et al. EMBO J, 1997 Jun 2. PMID 9214641, Free PMC Article
    4. A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression. Bolognesi B, et al. Cell Rep, 2016 Jun 28. PMID 27320918, Free PMC Article
    5. Mip6 binds directly to the Mex67 UBA domain to maintain low levels of Msn2/4 stress-dependent mRNAs. Martín-Expósito M, et al. EMBO Rep, 2019 Dec 5. PMID 31680439, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mip6 directly interacts with the ubiquitin-associated domain of Mex67 through a loop containing tryptophan 442. Mip6 shuttles between the nucleus and the cytoplasm in a Mex67-dependent manner and concentrates in cytoplasmic foci under stress.
      Title: Mip6 binds directly to the Mex67 UBA domain to maintain low levels of Msn2/4 stress-dependent mRNAs.
    2. This report describes the characterization of two related NDT80-induced genes, PES4 and MIP6, encoding predicted RNA binding proteins. These genes are necessary to regulate the steady-state expression, translational timing, and localization of a set of mRNAs that are transcribed by NDT80 but not translated until the end of meiosis II.
      Title: Predicted RNA Binding Proteins Pes4 and Mip6 Regulate mRNA Levels, Translation, and Localization during Sporulation in Budding Yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA localization resulting in post-transcriptional regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sporulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mip6p
    NP_011879.1
    • mRNA-binding protein; interacts with the UBA domain of mRNA export factor Mex67p; participates in the export of Msn2/4 stress-dependent mRNAs; partially redundant function with paralog PES4 in the steady-state expression, translational timing and localization of a subset of Ndt80-dependent mRNAs that are protected until translated near the end of meiosis II; redundant role with PES4 in sporulation; shuttles between the nucleus and cytoplasm, localizes to stress granules and the prospore membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      134554..136533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179145.1 → NP_011879.1  TPA: Mip6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011879.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKW0, P38760
      UniProtKB/TrEMBL
      A6ZSR9, B3LSD6, C7GXB0, C8ZA82, G2WF83, N1P2R4
      Conserved Domains (5) summary
      COG0724
      Location:8 → 187
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd21601
      Location:111 → 190
      RRM1_PES4_MIP6; RNA recognition motif 1 (RRM1) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins
      cd21602
      Location:200 → 275
      RRM2_PES4_MIP6; RNA recognition motif 2 (RRM2) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins
      cd21603
      Location:313 → 385
      RRM3_PES4_MIP6; RNA recognition motif 3 (RRM3) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins
      cd21604
      Location:400 → 478
      RRM4_PES4_MIP6; RNA recognition motif 4 (RRM4) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38760.1

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