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    clr5 silencing factor Clr5 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542669, updated on 10-Jul-2024

    Summary

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    Gene symbol
    clr5
    Gene description
    silencing factor Clr5
    Locus tag
    SPOM_SPAC29B12.08
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPAC29B12.08
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    Genomic context

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    See clr5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (5428356..5431523)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene plasma membrane glutathione transmembrane transporter Pgt1 Neighboring gene WW domain-binding protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases. Hansen KR, et al. PLoS Genet, 2011 Jan 6. PMID 21253571, Free PMC Article
    2. Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast. Nguyen TT, et al. Sci Rep, 2015 Feb 11. PMID 25669599, Free PMC Article
    3. Systematic analysis reveals the prevalence and principles of bypassable gene essentiality. Li J, et al. Nat Commun, 2019 Mar 1. PMID 30824696, Free PMC Article
    4. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article
    5. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. find that Clr5 controls gene expression at multiple chromosomal locations in addition to affecting the mating-type region
      Title: H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in silent mating-type cassette heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    silencing factor Clr5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5428356..5431523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020417.4 → NP_594986.3  silencing factor Clr5 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594986.3

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14030
      Conserved Domains (1) summary
      pfam14420
      Location:3 → 51
      Clr5; Clr5 domain
    Nucleotide Protein
    Heading Accession and Version

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