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    MED7 mediator complex subunit MED7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853985, updated on 17-May-2024

    Summary

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    Gene symbol
    MED7
    Gene description
    mediator complex subunit MED7
    Primary source
    FungiDB:YOL135C
    Locus tag
    YOL135C
    See related
    SGD:S000005495; AllianceGenome:SGD:S000005495; VEuPathDB:YOL135C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables transcription coactivator activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Part of core mediator complex. Orthologous to human MED7 (mediator complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MED7 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (69376..70044, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Bsc6p Neighboring gene 6-phosphofructo-2-kinase Neighboring gene SCF ubiquitin ligase complex subunit HRT1 Neighboring gene 1,3-beta-glucanosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis of a 12 801 bp fragment of the left arm of yeast chromosome XV containing a putative 6-phosphofructo-2-kinase gene, a gene for a possible glycophospholipid-anchored surface protein and six other open reading frames. Aldea M, et al. Yeast, 1996 Sep. PMID 8896270
    2. Mediator protein mutations that selectively abolish activated transcription. Myers LC, et al. Proc Natl Acad Sci U S A, 1999 Jan 5. PMID 9874773, Free PMC Article
    3. Fungal mediator tail subunits contain classical transcriptional activation domains. Liu Z, et al. Mol Cell Biol, 2015 Apr. PMID 25645928, Free PMC Article
    4. Role of Mediator in regulating Pol II elongation and nucleosome displacement in Saccharomyces cerevisiae. Kremer SB, et al. Genetics, 2012 May. PMID 22377631, Free PMC Article
    5. Functional and physical interactions within the middle domain of the yeast mediator. Hallberg M, et al. Mol Genet Genomics, 2006 Aug. PMID 16758199

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mediator complex subunit MED7
    NP_014506.1
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      69376..70044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183389.1 → NP_014506.1  TPA: mediator complex subunit MED7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014506.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1T4, Q08278
      UniProtKB/TrEMBL
      A0A6V8RKA4, A6ZN77, B3LIT2, B5VRC6, C7GV10, C8ZHI2, G2WMA3, N1NYH4
      Conserved Domains (1) summary
      pfam05983
      Location:21 → 203
      Med7; MED7 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08278.1

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