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    HIS3 imidazoleglycerol-phosphate dehydratase HIS3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854377, updated on 29-Jun-2024

    Summary

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    Gene symbol
    HIS3
    Gene description
    imidazoleglycerol-phosphate dehydratase HIS3
    Primary source
    FungiDB:YOR202W
    Locus tag
    YOR202W
    See related
    SGD:S000005728; AllianceGenome:SGD:S000005728; VEuPathDB:YOR202W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HIS10; HIS8
    Summary
    Enables imidazoleglycerol-phosphate dehydratase activity. Involved in histidine biosynthetic process. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HIS3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (721946..722608)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Bfr1p Neighboring gene Mrm1p Neighboring gene DEAD-box ATP-dependent RNA helicase DED1 Neighboring gene Gep3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape. Pokusaeva VO, et al. PLoS Genet, 2019 Apr. PMID 30969963, Free PMC Article
    2. Cloning and functional verification of the Candida milleri HIS3 gene encoding imidazoleglycerol phosphate dehydratase. Park EH, et al. J Microbiol Biotechnol, 2012 Oct. PMID 23075797
    3. Synthetic gene recruitment reveals adaptive reprogramming of gene regulation in yeast. Stolovicki E, et al. Genetics, 2006 May. PMID 16510783, Free PMC Article
    4. Eliminating gene conversion improves high-throughput genetics in Saccharomyces cerevisiae. Daniel JA, et al. Genetics, 2006 Jan. PMID 16157664, Free PMC Article
    5. A DNA region of Torulaspora delbrueckii containing the HIS3 gene: sequence, gene order and evolution. Aller-Arranz E, et al. Yeast, 2003 Dec. PMID 14663828

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structure of Sc_IGPD reveals that a 24-amino acid insertion forms an extended loop region on the enzyme surface that lies adjacent to the active site, forming interactions with the substrate/inhibitor binding loop that may influence inhibitor potency.
      Title: Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.
    2. Snf1 protein is important for HIS3 expression
      Title: Histone H3 Ser10 phosphorylation-independent function of Snf1 and Reg1 proteins rescues a gcn5- mutant in HIS3 expression.
    3. We propose that Gcn4p stimulates nucleosome mobilization over the entire HIS3 gene by the SWI/SNF complex. We suggest that the net effect of interplay among remodeling machines at HIS3 is to create a highly dynamic chromatin structure.
      Title: Activation of Saccharomyces cerevisiae HIS3 results in Gcn4p-dependent, SWI/SNF-dependent mobilization of nucleosomes over the entire gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables imidazoleglycerol-phosphate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables imidazoleglycerol-phosphate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables imidazoleglycerol-phosphate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables imidazoleglycerol-phosphate dehydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-histidine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-histidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    imidazoleglycerol-phosphate dehydratase HIS3
    NP_014845.1
    • Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      721946..722608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183621.1 → NP_014845.1  TPA: imidazoleglycerol-phosphate dehydratase HIS3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014845.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2Q9, P06633, Q12695, Q70D78, Q70D79, Q70D81, Q70D83
      UniProtKB/TrEMBL
      A0A8H4BV13, A6ZP46, B5VS85, C7GWH9, C8ZGV8, G2WN75, N1NYM2
      Conserved Domains (1) summary
      COG0131
      Location:1 → 219
      HisB2; Imidazoleglycerol phosphate dehydratase HisB [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06633.2

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