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    gtr2 RagC/D GTPase Gtr2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539088, updated on 22-Jun-2024

    Summary

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    Gene symbol
    gtr2
    Gene description
    RagC/D GTPase Gtr2
    Locus tag
    SPOM_SPCC777.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPCC777.05
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    Genomic context

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    See gtr2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1605093..1606539)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene cysteine desulfurase nifs family protein Neighboring gene ncRNA Neighboring gene amino acid transporter Dip5 Neighboring gene hydrolase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TORC1 signaling is governed by two negative regulators in fission yeast. Ma N, et al. Genetics, 2013 Oct. PMID 23934889, Free PMC Article
    2. The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. Valbuena N, et al. J Cell Sci, 2012 Apr 15. PMID 22344254, Free PMC Article
    3. The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast. Ma N, et al. PLoS One, 2016. PMID 27227887, Free PMC Article
    4. Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway. Laor D, et al. Mol Cell Biol, 2014 Mar. PMID 24344203, Free PMC Article
    5. Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases. Chia KH, et al. Elife, 2017 Dec 4. PMID 29199950, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids.
      Title: The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell cycle switching, mitotic to meiotic cell cycle EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Gtr1-Gtr2 GTPase complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of Gtr1-Gtr2 GTPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Gtr1-Gtr2 GTPase complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of Gtr1-Gtr2 GTPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in fungal-type vacuole membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RagC/D GTPase Gtr2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1605093..1606539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023241.3 → NP_588251.1  RagC/D GTPase Gtr2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588251.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74544
      Conserved Domains (2) summary
      cd11385
      Location:5 → 177
      RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
      COG1100
      Location:1 → 155
      Gem1; GTPase SAR1 family domain [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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