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    ARC18 Arc18p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851085, updated on 17-May-2024

    Summary

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    Gene symbol
    ARC18
    Gene description
    Arc18p
    Primary source
    FungiDB:YLR370C
    Locus tag
    YLR370C
    See related
    SGD:S000004362; AllianceGenome:SGD:S000004362; VEuPathDB:YLR370C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable actin binding activity. Predicted to contribute to actin filament binding activity. Involved in actin cortical patch organization and establishment of mitochondrion localization. Located in mitochondrion. Part of Arp2/3 protein complex. Orthologous to human ARPC3 (actin related protein 2/3 complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARC18 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (861718..862254, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene SCF ubiquitin ligase complex subunit MDM30 Neighboring gene Hsp70 family ATPase SSQ1 Neighboring gene Rho family guanine nucleotide exchange factor ROM2 Neighboring gene fatty acid elongase ELO3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Actin polymerization driven mitochondrial transport in mating S. cerevisiae. Senning EN, et al. Proc Natl Acad Sci U S A, 2010 Jan 12. PMID 20080741, Free PMC Article
    2. A role for Jsn1p in recruiting the Arp2/3 complex to mitochondria in budding yeast. Fehrenbacher KL, et al. Mol Biol Cell, 2005 Nov. PMID 16107558, Free PMC Article
    3. Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes. Qureshi MS, et al. Anal Biochem, 2013 Aug 1. PMID 23583819
    4. Purification of Arp2/3 complex from Saccharomyces cerevisiae. Doolittle LK, et al. Methods Mol Biol, 2013. PMID 23868593, Free PMC Article
    5. Functional surfaces on the p35/ARPC2 subunit of Arp2/3 complex required for cell growth, actin nucleation, and endocytosis. Daugherty KM, et al. J Biol Chem, 2008 Jun 13. PMID 18381280, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARC18 protein mutant was found to be defective in apical actin patch localization.
      Title: Comprehensive and quantitative analysis of yeast deletion mutants defective in apical and isotropic bud growth.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cortical patch organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Arc18p
    NP_013474.3
    • Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      861718..862254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182259.3 → NP_013474.3  TPA: Arc18p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013474.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ07, Q05933
      UniProtKB/TrEMBL
      A0A6A5PUQ2, A7A1P7, B3RHN7, C7GRW4, C8ZDY0, G2WJI7, N1P796
      Conserved Domains (1) summary
      pfam04062
      Location:1 → 178
      P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05933.1

    Gene LinkOut

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