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    CDC1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851763, updated on 11-Sep-2024

    Summary

    Official Symbol
    CDC1
    Primary source
    SGD:S000002590
    Locus tag
    YDR182W
    See related
    AllianceGenome:SGD:S000002590; FungiDB:YDR182W; VEuPathDB:YDR182W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DSC1; DSR1; ESP2
    Summary
    Predicted to enable hydrolase activity and metal ion binding activity. Involved in DNA repair. Acts upstream of or within GPI anchor biosynthetic process. Located in endoplasmic reticulum. Orthologous to human MPPE1 (metallophosphoesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (827582..829057)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene cohesin-loading factor complex subunit SCC2 Neighboring gene Sas4p Neighboring gene uncharacterized protein Neighboring gene Plp1p

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in GPI anchor biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    putative lipid phosphatase CDC1
    NP_010468.1
    • Putative mannose-ethanolamine phosphate phosphodiesterase; involved in GPI-anchor remodeling prior to the attachment of cell wall proteins to beta 1,3-glucan, removing ethanolamine phosphate from the first mannose of GPI anchors; mutants display elevated Ca2+-dependent signaling resulting in secondary actin polarization and Golgi inheritance defects; enzyme is Mn2+-dependent; mutants have cell division cycle defect and fragile cell walls

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      827582..829057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180490.1NP_010468.1  TPA: putative lipid phosphatase CDC1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010468.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSG5, P40986
      UniProtKB/TrEMBL
      B3LGA0, B5VG76, C7GN14, C8Z596, G2WAT1
      Conserved Domains (1) summary
      cd08163
      Location:91347
      MPP_Cdc1; Saccharomyces cerevisiae CDC1 and related proteins, metallophosphatase domain