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    sds22 serine/threonine protein phosphatase PP1 regulatory subunit Sds22 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543597, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sds22
    Official Full Name
    serine/threonine protein phosphatase PP1 regulatory subunit Sds22
    Primary source
    PomBase:SPAC4A8.12c
    Locus tag
    SPOM_SPAC4A8.12C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See sds22 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (2573160..2574541, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene fatty acid synthase alpha subunit Fas2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ribose-phosphate pyrophosphokinase Neighboring gene 20S proteasome complex subunit beta 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitotic regulation of protein phosphatases by the fission yeast sds22 protein. Stone EM, et al. Curr Biol, 1993 Jan. PMID 15335873
    2. S. pombe gene sds22+ essential for a midmitotic transition encodes a leucine-rich repeat protein that positively modulates protein phosphatase-1. Ohkura H, et al. Cell, 1991 Jan 11. PMID 1846086
    3. CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation. Vanoosthuyse V, et al. PLoS Genet, 2014 Jun. PMID 24945319, Free PMC Article
    4. Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast. Burr R, et al. J Biol Chem, 2017 Sep 29. PMID 28821619, Free PMC Article
    5. Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. Nie M, et al. J Biol Chem, 2012 Aug 24. PMID 22730331, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein phosphatase activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signaling NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    part_of PTW/PP1 phosphatase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine protein phosphatase PP1 regulatory subunit Sds22

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2573160..2574541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019253.3 → NP_593824.1  serine/threonine protein phosphatase PP1 regulatory subunit Sds22 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593824.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P22194
      Conserved Domains (4) summary
      smart00446
      Location:302 → 320
      LRRcap; occurring C-terminal to leucine-rich repeats
      sd00033
      Location:84 → 105
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:104 → 146
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:217 → 271
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version

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