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    BUD4 Bud4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853554, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BUD4
    Official Full Name
    Bud4p
    Primary source
    SGD:S000003852
    Locus tag
    YJR092W
    See related
    AllianceGenome:SGD:S000003852; FungiDB:YJR092W; VEuPathDB:YJR092W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTP binding activity. Involved in axial cellular bud site selection; protein localization to bud neck; and septin ring organization. Located in cellular bud neck contractile ring and cellular bud scar. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BUD4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (598735..603078)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene SCF ubiquitin ligase complex subunit GRR1 Neighboring gene Jsn1p Neighboring gene cleavage polyadenylation factor subunit FIP1 Neighboring gene transcription factor IME1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Off-target effects of the septin drug forchlorfenuron on nonplant eukaryotes. Heasley LR, et al. Eukaryot Cell, 2014 Nov. PMID 25217460, Free PMC Article
    2. Adhesion in Candida spp. Sundstrom P. Cell Microbiol, 2002 Aug. PMID 12174081
    3. The BUD4 protein of yeast, required for axial budding, is localized to the mother/BUD neck in a cell cycle-dependent manner. Sanders SL, et al. J Cell Biol, 1996 Jul. PMID 8707826, Free PMC Article
    4. Critical Roles of a RhoGEF-Anillin Module in Septin Architectural Remodeling during Cytokinesis. Chen X, et al. Curr Biol, 2020 Apr 20. PMID 32197082, Free PMC Article
    5. Coupling of septins to the axial landmark by Bud4 in budding yeast. Kang PJ, et al. J Cell Sci, 2013 Mar 1. PMID 23345395, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Critical Roles of a RhoGEF-Anillin Module in Septin Architectural Remodeling during Cytokinesis.
      Title: Critical Roles of a RhoGEF-Anillin Module in Septin Architectural Remodeling during Cytokinesis.
    2. Bud4 plays a role in septin organization during bud growth. The central region of Bud4 functionally interacts with the septin ring.
      Title: The anillin-related region of Bud4 is the major functional determinant for Bud4's function in septin organization during bud growth and axial bud site selection in budding yeast.
    3. The results indicate that Bud4 functions as a platform that links septins to the axial landmark.
      Title: Coupling of septins to the axial landmark by Bud4 in budding yeast.
    4. Findings suggest that Bud4 plays a critical role in the assembly of the axial landmark and its link to the Rsr1 GTPase module.
      Title: Bud4 mediates the cell-type-specific assembly of the axial landmark in budding yeast.
    5. The Bud4, a long with Gin4 and cla4, is part of a complex network that regulates septins organizaon at the time of cytokinesis.
      Title: Cdk and the anillin homolog Bud4 define a new pathway regulating septin organization in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axial cellular bud site selection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axial cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to bud neck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to bud neck IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septin ring organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular bud neck contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud scar IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bud4p
    NP_012625.5
    • Anillin-like protein involved in bud-site selection; required for the axial budding pattern; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; functions as a platform linking the cytokinesis tag septins to the axial landmark through its multiple domains; in vivo substrate of Cdc28p/Clb2p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      598735..603078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181749.3 → NP_012625.5  TPA: Bud4p [Saccharomyces cerevisiae S288C]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWR0, P47136
      UniProtKB/TrEMBL
      C7GMB5
      Conserved Domains (2) summary
      COG5271
      Location:221 → 618
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd13278
      Location:1285 → 1424
      PH_Bud4; Bud4 Pleckstrin homology (PH) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47136.2

    Gene LinkOut

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