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    apc10 anaphase-promoting complex substrate recognition subunit Apc10 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540307, updated on 22-Jun-2024

    Summary

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    Gene symbol
    apc10
    Gene description
    anaphase-promoting complex substrate recognition subunit Apc10
    Locus tag
    SPOM_SPBC1A4.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPBC1E8.06
    Old locus tag
    SPBC1A4.01
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    Genomic context

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    See apc10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (1973362..1974265)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein knh4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 3-isopropylmalate dehydrogenase Leu1 Neighboring gene DNA topoisomerase II

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Overexpression of the apc10+ gene in the fission yeast Schizosaccharomyces pombe can suppress temperature sensitivity of the nuc2-663 mutant,but not its sterility]. Grishchuk EL, et al. Mol Biol (Mosk), 2000 Sep-Oct. PMID 11033806
    2. Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast. Kominami K, et al. EMBO J, 1998 Sep 15. PMID 9736616, Free PMC Article
    3. Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin. Kimata Y, et al. J Cell Sci, 2008 Apr 1. PMID 18354085
    4. A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securin plasmids. Matsumura T, et al. Genes Cells, 2003 Apr. PMID 12653962
    5. Role of Hcn1 and its phosphorylation in fission yeast anaphase-promoting complex/cyclosome function. Yoon HJ, et al. J Biol Chem, 2006 Oct 27. PMID 16950791

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    anaphase-promoting complex substrate recognition subunit Apc10

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1973362..1974265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021705.3 → NP_595803.1  anaphase-promoting complex substrate recognition subunit Apc10 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595803.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42971
      Conserved Domains (1) summary
      COG5156
      Location:1 → 189
      DOC1; Anaphase-promoting complex (APC), subunit 10 [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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