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    PSE1 Pse1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855356, updated on 1-Aug-2024

    Summary

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    Gene symbol
    PSE1
    Gene description
    Pse1p
    Primary source
    FungiDB:YMR308C
    Locus tag
    YMR308C
    See related
    SGD:S000004925; AllianceGenome:SGD:S000004925; VEuPathDB:YMR308C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KAP121
    Summary
    Enables nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in nucleocytoplasmic transport; regulation of mitotic nuclear division; and regulation of protein desumoylation. Located in cytoplasm and nucleus. Used to study cancer. Orthologous to several human genes including IPO5 (importin 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PSE1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (888952..892221, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative 1,3-beta-D-glucan synthase Neighboring gene 1,3-beta-glucanosyltransferase GAS1 Neighboring gene translation initiation factor eIF3 core subunit c Neighboring gene putative methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Screening and identification of a gene, PSE-1, that affects protein secretion in Saccharomyces cerevisiae. Chow TY, et al. J Cell Sci, 1992 Mar. PMID 1522152
    2. Crystal structure of the karyopherin Kap121p bound to the extreme C-terminus of the protein phosphatase Cdc14p. Kobayashi J, et al. Biochem Biophys Res Commun, 2015 Jul 31. PMID 26022122
    3. Functional and physical interactions between autonomously replicating sequence-binding factor 1 and the nuclear transport machinery. Loch CM, et al. Traffic, 2004 Dec. PMID 15522095
    4. Pse1p mediates the nuclear import of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae. Ueta R, et al. J Biol Chem, 2003 Dec 12. PMID 14523005
    5. The core protein of hepatitis C virus is imported into the nucleus by transport receptor Kap123p but inhibits Kap121p-dependent nuclear import of yeast AP1-like transcription factor in yeast cells. Isoyama T, et al. J Biol Chem, 2002 Oct 18. PMID 12167639

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RanGTP-resistant interactions of Kap121 with the Dam1 complex would allow Kap121 to escort the complex to its destination on kinetochore-associated microtubule ends.
      Title: The Nuclear Transport Factor Kap121 Is Required for Stability of the Dam1 Complex and Mitotic Kinetochore Bi-orientation.
    2. The crystal structure of Kap121p-Cdc14p complex is determined.
      Title: Crystal structure of the karyopherin Kap121p bound to the extreme C-terminus of the protein phosphatase Cdc14p.
    3. Comparison of the nuclear localization signal and RanGTP complexes reveals that RanGTP binding not only occludes the cargo-binding site but also forces Kap121p into a conformation that is incompatible with nuclear localization signal recognition.
      Title: Structural basis for cell-cycle-dependent nuclear import mediated by the karyopherin Kap121p.
    4. The PSE1 specifically binds to histones H2A and H2B.
      Title: The histones H2A/H2B and H3/H4 are imported into the yeast nucleus by different mechanisms.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nuclear import signal receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein desumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein desumoylation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pse1p
    NP_014039.1
    • Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p; required for stability of the Dam1p-Duo1p complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      888952..892221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182819.1 → NP_014039.1  TPA: Pse1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014039.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0D5, P32337
      UniProtKB/TrEMBL
      B3LMJ6, C7GPV5, G2WL17, N1NYW3
      Conserved Domains (6) summary
      sd00044
      Location:106 → 128
      HEAT; HEAT repeat [structural motif]
      pfam13513
      Location:396 → 435
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:403 → 475
      HEAT_2; HEAT repeats
      pfam18808
      Location:274 → 365
      Importin_rep_4; Importin repeat
      pfam18816
      Location:1001 → 1054
      Importin_rep_5; Importin repeat
      pfam18829
      Location:766 → 868
      Importin_rep_6; Importin repeat 6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32337.2

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