NYV1 Nyv1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: NYV1
Gene description: Nyv1p
Primary source: FungiDB:YLR093C
Locus tag: YLR093C
See related: SGD:S000004083; AllianceGenome:SGD:S000004083; VEuPathDB:YLR093C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MAM2
Summary: Enables SNAP receptor activity. Involved in vacuole fusion, non-autophagic and vesicle fusion. Located in fungal-type vacuole membrane. Part of SNARE complex. Orthologous to human VAMP5 (vesicle associated membrane protein 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NYV1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 2

Sequence:: Chromosome: XII; NC_001144.5 (326513..327415, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lipid-anchored Vti1 was fully active, and lipid-anchored Nyv1 permitted the reaction to proceed up to hemifusion, and lipid-anchored Vam3 interfered already before hemifusion.
Title: Vacuolar SNARE protein transmembrane domains serve as nonspecific membrane anchors with unequal roles in lipid mixing.
To demonstrate unequivocally the fusion activity of lipid-anchored Nyv1p, we reconstituted proteoliposomes with purified lipid-anchored Nyv1p as the only protein.
Title: A lipid-anchored SNARE supports membrane fusion.
Although the sorting of Nyv1p to the limiting membrane of the vacuole is dependent upon the Y31GTI34 motif, and Y31 in particular, our findings suggest a mechanistically distinct role for this subunit in the recognition of YXX phi-like sorting signals.
Title: Identification of the yeast R-SNARE Nyv1p as a novel longin domain-containing protein.
during vacuole fusion, Nyv1 is the classical R-SNARE, whereas the Ykt6-containing complex has a novel function in Vac8 palmitoylation
Title: ATP-independent control of Vac8 palmitoylation by a SNARE subcomplex on yeast vacuoles.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in vacuole fusion, non-autophagic	IDA Inferred from Direct Assay more info	PubMed
involved_in vacuole fusion, non-autophagic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle fusion	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SNARE complex	IDA Inferred from Direct Assay more info	PubMed
part_of SNARE complex	IEA Inferred from Electronic Annotation more info
located_in bounding membrane of organelle	IEA Inferred from Electronic Annotation more info
located_in fungal-type vacuole membrane	HDA more info	PubMed
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nyv1p

NP_013194.2

v-SNARE component of vacuolar SNARE complex; involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in vacuolar membrane; targeted to vacuole via AP-3 pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

326513..327415 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181980.1 → NP_013194.2 TPA: Nyv1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013194.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VY93, Q12255

UniProtKB/TrEMBL

A7A0Z7, B3LT61, C8ZD63, N1P6H4

Conserved Domains (2) summary

pfam00957
Location:165 → 250

Synaptobrevin

pfam09426
Location:6 → 144

Nyv1_N; Vacuolar R-SNARE Nyv1 N terminal