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    NGL1 RNA exonuclease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854115, updated on 17-May-2024

    Summary

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    Gene symbol
    NGL1
    Gene description
    RNA exonuclease
    Primary source
    FungiDB:YOL042W
    Locus tag
    YOL042W
    See related
    SGD:S000005402; AllianceGenome:SGD:S000005402; VEuPathDB:YOL042W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable endonuclease activity and poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Located in mitochondrion. Orthologous to human CNOT6L (CCR4-NOT transcription complex subunit 6 like). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NGL1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (249825..250916)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Pex15p Neighboring gene bifunctional N-glycosylase/AP lyase NTG2 Neighboring gene Nop12p Neighboring gene ribosomal 40S subunit protein S15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiae. Faber AW, et al. RNA, 2002 Sep. PMID 12358428, Free PMC Article
    2. Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding. Dupressoir A, et al. BMC Genomics, 2001. PMID 11747467, Free PMC Article
    3. Yeast mitochondrial RNase P, RNase Z and the RNA degradosome are part of a stable supercomplex. Daoud R, et al. Nucleic Acids Res, 2012 Feb. PMID 22034500, Free PMC Article
    4. A genomic analysis of chronological longevity factors in budding yeast. Burtner CR, et al. Cell Cycle, 2011 May 1. PMID 21447998, Free PMC Article
    5. Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. Srikumar T, et al. J Cell Biol, 2013 Apr 1. PMID 23547032, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA exonuclease
    NP_014600.1
    • Putative endonuclease; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      249825..250916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183296.1 → NP_014600.1  TPA: RNA exonuclease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014600.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W224, Q08213
      UniProtKB/TrEMBL
      A0A6A5Q6L1, A6ZNG7, B3LJ16, B5VRL1, C7GK11, G2WMJ1, N1NWR0
      Conserved Domains (1) summary
      COG5239
      Location:1 → 363
      CCR4; mRNA deadenylase, 3'-5' endonuclease subunit Ccr4 [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08213.1

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