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    BPH1 Bph1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850398, updated on 7-Jul-2024

    Summary

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    Gene symbol
    BPH1
    Gene description
    Bph1p
    Primary source
    FungiDB:YCR032W
    Locus tag
    YCR032W
    See related
    SGD:S000000628; AllianceGenome:SGD:S000000628; VEuPathDB:YCR032W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein kinase binding activity. Involved in fungal-type cell wall organization; intracellular protein transport; and response to pH. Located in cytosol. Is extrinsic component of membrane. Used to study Chediak-Higashi syndrome. Human ortholog(s) of this gene implicated in primary autosomal dominant microcephaly 18. Orthologous to human WDFY3 (WD repeat and FYVE domain containing 3) and WDFY4 (WDFY family member 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BPH1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (179520..186023)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S14A Neighboring gene ncRNA Neighboring gene Snt1p Neighboring gene fatty acid elongase ELO2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast LYST homolog Bph1 is a Rab5 effector and prevents Atg8 lipidation at endosomes. Vargas Duarte P, et al. J Cell Sci, 2022 Apr 15. PMID 35343566
    2. The sequence of 8.8 kb of yeast chromosome III cloned in lambda PM3270 contains an unusual long ORF (YCR601). Rodriguez F, et al. Yeast, 1991 Aug-Sep. PMID 1837415
    3. Functionally Related Genes Cluster into Genomic Regions That Coordinate Transcription at a Distance in Saccharomyces cerevisiae. Cera A, et al. mSphere, 2019 Mar 13. PMID 30867326, Free PMC Article
    4. Large-scale phenotypic analysis--the pilot project on yeast chromosome III. Rieger KJ, et al. Yeast, 1997 Dec. PMID 9509574
    5. Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting. Shiflett SL, et al. Traffic, 2004 Sep. PMID 15296494

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. associates with a membrane and is involved in protein sorting and cell wall formation
      Title: Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein lipidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Bph1p
    NP_009961.2
    • Endosomal protein involved in endocytosis and autophagy; homologous to Chediak-Higashi syndrome and Beige proteins, both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      179520..186023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178746.1 → NP_009961.2  TPA: Bph1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009961.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR42, P25356, Q02396, Q07348
      UniProtKB/TrEMBL
      A0A8H4BTH2, C8Z4C2
      Conserved Domains (3) summary
      smart01026
      Location:1558 → 1839
      Beach; Beige/BEACH domain
      cd01201
      Location:1371 → 1500
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:1933 → 1976
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25356.2

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