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    RUB1 NEDD8 family protein RUB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851717, updated on 29-Jun-2024

    Summary

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    Gene symbol
    RUB1
    Gene description
    NEDD8 family protein RUB1
    Primary source
    FungiDB:YDR139C
    Locus tag
    YDR139C
    See related
    SGD:S000002546; AllianceGenome:SGD:S000002546; VEuPathDB:YDR139C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein tag. Involved in protein neddylation. Located in cytoplasm. Orthologous to human NEDD8 (NEDD8 ubiquitin like modifier). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RUB1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_001136.10 (733618..733924, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Rgp1p Neighboring gene Hpr1p Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene Dop1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress. Pick E. Redox Biol, 2020 Oct. PMID 33099217, Free PMC Article
    2. An improved SUMmOn-based methodology for the identification of ubiquitin and ubiquitin-like protein conjugation sites identifies novel ubiquitin-like protein chain linkages. Jeram SM, et al. Proteomics, 2010 Jan. PMID 20029837, Free PMC Article
    3. Rub1p processing by Yuh1p is required for wild-type levels of Rub1p conjugation to Cdc53p. Linghu B, et al. Eukaryot Cell, 2002 Jun. PMID 12455997, Free PMC Article
    4. A novel protein modification pathway related to the ubiquitin system. Liakopoulos D, et al. EMBO J, 1998 Apr 15. PMID 9545234, Free PMC Article
    5. The cyclomodulin cycle inhibiting factor (CIF) alters cullin neddylation dynamics. Toro TB, et al. J Biol Chem, 2013 May 24. PMID 23589306, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress.
      Title: The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress.
    2. A dual E3 mechanism for Rub1 ligation to Cdc53.
      Title: A dual E3 mechanism for Rub1 ligation to Cdc53.
    3. DCN1 directly interacts with the Nedd8 E2 Ubc12 on a surface that overlaps with the E1-binding site. Nedd8.
      Title: Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation.
    4. DCN-1 directly bind Nedd8 and physically associate with cullins
      Title: The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tag activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein neddylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein neddylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NEDD8 family protein RUB1
    NP_010423.4
    • Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      733618..733924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180446.3 → NP_010423.4  TPA: NEDD8 family protein RUB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010423.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSC2, Q03919
      UniProtKB/TrEMBL
      A6ZY99, B3LGE0, C7GIP4, C8Z555, G2WAN9, N1P4T1
      Conserved Domains (1) summary
      cd01806
      Location:3 → 76
      Ubl_NEDD8; ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03919.1

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