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    TDA5 Tda5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851146, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TDA5
    Official Full Name
    Tda5p
    Primary source
    SGD:S000004418
    Locus tag
    YLR426W
    See related
    AllianceGenome:SGD:S000004418; FungiDB:YLR426W; VEuPathDB:YLR426W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in response to xenobiotic stimulus. Located in endoplasmic reticulum and mitochondrion. Orthologous to several human genes including DHRS3 (dehydrogenase/reductase 3); HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11); and HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TDA5 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    2
    Sequence:
    Chromosome: XII; NC_001144.5 (987062..988113)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene Rho family guanine nucleotide exchange factor TUS1 Neighboring gene Mag2p Neighboring gene Crn1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Use of a genome-wide approach to identify new genes that control resistance of Saccharomyces cerevisiae to ionizing radiation. Game JC, et al. Radiat Res, 2003 Jul. PMID 12816519
    2. Chemogenetic E-MAP in Saccharomyces cerevisiae for Identification of Membrane Transporters Operating Lipid Flip Flop. Vazquez HM, et al. PLoS Genet, 2016 Jul. PMID 27462707, Free PMC Article
    3. Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. Lee W, et al. PLoS Genet, 2005 Aug. PMID 16121259, Free PMC Article
    4. Identification and characterization of Prp45p and Prp46p, essential pre-mRNA splicing factors. Albers M, et al. RNA, 2003 Jan. PMID 12554883, Free PMC Article
    5. A Genetic Screen To Identify Genes Influencing the Secondary Redox Couple NADPH/NADP(+) in the Yeast Saccharomyces cerevisiae. Yadav S, et al. G3 (Bethesda), 2020 Jan 7. PMID 31757928, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to xenobiotic stimulus HMP PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tda5p
    NP_013530.1
    • hypothetical protein; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      987062..988113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182314.1 → NP_013530.1  TPA: Tda5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013530.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ62, Q06417
      UniProtKB/TrEMBL
      A7A1U7, B3RHT6, C8ZE34, G2WJN8, N1P1X5
      Conserved Domains (1) summary
      cl21454
      Location:72 → 309
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06417.1

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