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    MRX16 Mrx16p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851710, updated on 7-Jul-2024

    Summary

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    Gene symbol
    MRX16
    Gene description
    Mrx16p
    Primary source
    FungiDB:YDR132C
    Locus tag
    YDR132C
    See related
    SGD:S000002539; AllianceGenome:SGD:S000002539; VEuPathDB:YDR132C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in protein homooligomerization. Located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MRX16 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (718816..720303, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Fin1p Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene ATP-binding cassette glutathione S-conjugate transporter YCF1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation. Menon BB, et al. Proc Natl Acad Sci U S A, 2005 Apr 19. PMID 15817685, Free PMC Article
    2. The ribosome receptors Mrx15 and Mba1 jointly organize cotranslational insertion and protein biogenesis in mitochondria. Möller-Hergt BV, et al. Mol Biol Cell, 2018 Oct 1. PMID 30091672, Free PMC Article
    3. Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes. del Alamo M, et al. PLoS Biol, 2011 Jul. PMID 21765803, Free PMC Article
    4. The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome. Niepel M, et al. Mol Biol Cell, 2013 Dec. PMID 24152732, Free PMC Article
    5. Annotating novel genes by integrating synthetic lethals and genomic information. Schöner D, et al. BMC Syst Biol, 2008 Jan 14. PMID 18194531, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mrx16p
    NP_010417.3
    • Protein that associates with the large mitoribosomal subunit; abundance and relative nuclear distribution to the protein increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      718816..720303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180440.3 → NP_010417.3  TPA: Mrx16p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010417.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSB8, Q03900
      UniProtKB/TrEMBL
      A0A8H8UN45, A6ZY93, B3LGE5, C7GIP0, C8Z548
      Conserved Domains (1) summary
      cd18316
      Location:30 → 121
      BTB_POZ_KCTD-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03900.1

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