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    gef1 RhoGEF for Cdc42 (Gef1) [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542635, updated on 22-Jun-2024

    Summary

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    Gene symbol
    gef1
    Gene description
    RhoGEF for Cdc42 (Gef1)
    Locus tag
    SPOM_SPAC24H6.09
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPAC24H6.09
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    Genomic context

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    See gef1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (469981..472990, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene sulfate transporter Neighboring gene phospho-2-dehydro-3-deoxyheptonate aldolase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Cdc42 GEF, Gef1, through endocytosis organizes F-BAR Cdc15 along the actomyosin ring and promotes concentric furrowing. Onwubiko UN, et al. J Cell Sci, 2019 Feb 28. PMID 30709916, Free PMC Article
    2. F-BAR Cdc15 Promotes Cdc42 Activation During Cytokinesis and Cell Polarization in Schizosaccharomyces pombe. Hercyk BS, et al. Genetics, 2019 Dec. PMID 31591131, Free PMC Article
    3. Gef1p and Scd1p, the Two GDP-GTP exchange factors for Cdc42p, form a ring structure that shrinks during cytokinesis in Schizosaccharomyces pombe. Hirota K, et al. Mol Biol Cell, 2003 Sep. PMID 12972551, Free PMC Article
    4. A novel interplay between GEFs orchestrates Cdc42 activity during cell polarity and cytokinesis in fission yeast. Hercyk BS, et al. J Cell Sci, 2019 Dec 3. PMID 31719163, Free PMC Article
    5. Unique spatiotemporal activation pattern of Cdc42 by Gef1 and Scd1 promotes different events during cytokinesis. Wei B, et al. Mol Biol Cell, 2016 Apr 15. PMID 26941334, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Microtubules and the Tea1-Tea4-Pom1 axis counteract inappropriate Gef1 activity by regulating the localization of the Cdc42 GTPase-activating protein Rga4.
      Title: Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and the Tea1-Tea4-Pom1 axis.
    2. Unique role of GEF1 in the regulation of distinct events during cytokinesis: Gef1 localizes first to the cytokinetic ring and promotes timely constriction.
      Title: Unique spatiotemporal activation pattern of Cdc42 by Gef1 and Scd1 promotes different events during cytokinesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of bipolar cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of bipolar cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic actomyosin contractile ring contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actomyosin contractile ring contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of division septum assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of division septum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment of cell polarity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex of growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in division septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endocytic patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in medial cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RhoGEF for Cdc42 (Gef1)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      469981..472990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018344.3 → NP_592943.1  RhoGEF for Cdc42 (Gef1) [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592943.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09763
      Conserved Domains (1) summary
      cd00160
      Location:312 → 505
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    Nucleotide Protein
    Heading Accession and Version

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