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    IZH4 Izh4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854052, updated on 29-Jun-2024

    Summary

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    Gene symbol
    IZH4
    Gene description
    Izh4p
    Primary source
    FungiDB:YOL101C
    Locus tag
    YOL101C
    See related
    SGD:S000005461; AllianceGenome:SGD:S000005461; VEuPathDB:YOL101C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable signaling receptor activity. Involved in cellular zinc ion homeostasis. Located in fungal-type vacuole and nucleus. Human ortholog(s) of this gene implicated in breast cancer; macular degeneration; non-alcoholic fatty liver disease; prostate adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human ADIPOR1 (adiponectin receptor 1) and ADIPOR2 (adiponectin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See IZH4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (126982..127920, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene myo-inositol transporter ITR2 Neighboring gene tRNA 2'-phosphotransferase Neighboring gene serine/threonine protein kinase PKH2 Neighboring gene Sdd3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic and preliminary phenotypic analysis of yeast PAQR receptors: potential antifungal targets. Villa NY, et al. J Mol Evol, 2011 Oct. PMID 22009226, Free PMC Article
    2. Metalloregulation of yeast membrane steroid receptor homologs. Lyons TJ, et al. Proc Natl Acad Sci U S A, 2004 Apr 13. PMID 15060275, Free PMC Article
    3. Disruption of six novel genes from the left arm of chromosome XV of Saccharomyces cerevisiae and basic phenotypic analysis of the generated mutants. Séron K, et al. Yeast, 1999 Jan 15. PMID 10028187
    4. Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis. Wendland B, et al. J Cell Biol, 1998 Apr 6. PMID 9531549, Free PMC Article
    5. A genome-wide screen in Saccharomyces cerevisiae reveals a critical role for the mitochondria in the toxicity of a trichothecene mycotoxin. McLaughlin JE, et al. Proc Natl Acad Sci U S A, 2009 Dec 22. PMID 20007368, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Izh4p
    NP_014540.1
    • Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress; IZH4 has a paralog, IZH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      126982..127920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183355.1 → NP_014540.1  TPA: Izh4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014540.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1W7, Q6B2Z2, Q99393
      UniProtKB/TrEMBL
      A0A8H4BUS4, A6ZNA8, B3LIW3, B5VRF4, C7GRV3, C8ZHL3, G2WMD4, N1NWB6
      Conserved Domains (1) summary
      cl03831
      Location:27 → 298
      HlyIII; Haemolysin-III related
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99393.1

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