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    KTR7 putative mannosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854724, updated on 29-Jun-2024

    Summary

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    Gene symbol
    KTR7
    Gene description
    putative mannosyltransferase
    Primary source
    FungiDB:YIL085C
    Locus tag
    YIL085C
    See related
    SGD:S000001347; AllianceGenome:SGD:S000001347; VEuPathDB:YIL085C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable alpha-1,2-mannosyltransferase activity. Involved in fungal-type cell wall organization. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See KTR7 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (200490..202043, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Aim19p Neighboring gene uncharacterized protein Neighboring gene Sds3p Neighboring gene phosphopantothenate--cysteine ligase CAB2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The KTR and MNN1 mannosyltransferase families of Saccharomyces cerevisiae. Lussier M, et al. Biochim Biophys Acta, 1999 Jan 6. PMID 9878809
    2. Saccharomyces cerevisiae KTR4, KTR5 and KTR7 encode mannosyltransferases differentially involved in the N- and O-linked glycosylation pathways. Hernández NV, et al. Res Microbiol, 2017 Oct. PMID 28774774
    3. Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism. Lussier M, et al. Yeast, 1997 Mar 15. PMID 9090056
    4. Distinct adaptor proteins assist exit of Kre2-family proteins from the yeast ER. Noda Y, et al. Biol Open, 2014 Mar 15. PMID 24585773, Free PMC Article
    5. Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae. Chen Y, et al. Mol Cancer Res, 2005 Dec. PMID 16380504

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KTR4, KTR5 and KTR7 have a redundant activity in the S. cerevisiae N-linked glycosylation pathway, but KTR4 plays a major role in O-linked glycan synthesis.
      Title: Saccharomyces cerevisiae KTR4, KTR5 and KTR7 encode mannosyltransferases differentially involved in the N- and O-linked glycosylation pathways.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall mannoprotein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative mannosyltransferase
    NP_012181.3
    • Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      200490..202043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179433.3 → NP_012181.3  TPA: putative mannosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012181.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVK1, P40504
      UniProtKB/TrEMBL
      A0A8H4C0A9, G2WG66
      Conserved Domains (1) summary
      COG5020
      Location:7 → 490
      KTR1; Mannosyltransferase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40504.1

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