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    ZWF1 glucose-6-phosphate dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855480, updated on 9-Jun-2024

    Summary

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    Gene symbol
    ZWF1
    Gene description
    glucose-6-phosphate dehydrogenase
    Primary source
    FungiDB:YNL241C
    Locus tag
    YNL241C
    See related
    SGD:S000005185; AllianceGenome:SGD:S000005185; VEuPathDB:YNL241C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MET19; POS10
    Summary
    Enables glucose-6-phosphate dehydrogenase activity. Involved in pentose-phosphate shunt, oxidative branch and response to hydrogen peroxide. Located in cytoplasm. Used to study congenital nonspherocytic hemolytic anemia. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cortisone reductase deficiency (multiple); favism; malaria (multiple); and neonatal jaundice. Orthologous to several human genes including G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ZWF1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (196426..197943, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Sla2p Neighboring gene Atg2p Neighboring gene iron-sulfur cluster assembly protein NAR1 Neighboring gene bleomycin hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tailoring strain construction strategies for muconic acid production in S. cerevisiae and E. coli. Averesch NJH, et al. Metab Eng Commun, 2014 Dec. PMID 34150501, Free PMC Article
    2. Bidirectional titration of yeast gene expression using a pooled CRISPR guide RNA approach. Bowman EK, et al. Proc Natl Acad Sci U S A, 2020 Aug 4. PMID 32690674, Free PMC Article
    3. Investigation of Heterologously Expressed Glucose-6-Phosphate Dehydrogenase Genes in a Yeast zwf1 Deletion. Heinisch JJ, et al. Microorganisms, 2020 Apr 9. PMID 32283834, Free PMC Article
    4. Protein expression analysis revealed a fine-tuned mechanism of in situ detoxification pathway for the tolerant industrial yeast Saccharomyces cerevisiae. Liu ZL, et al. Appl Microbiol Biotechnol, 2019 Jul. PMID 31139900
    5. Importance of glucose-6-phosphate dehydrogenase (G6PDH) for vanillin tolerance in Saccharomyces cerevisiae. Nguyen TT, et al. J Biosci Bioeng, 2014 Sep. PMID 24725964

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glucose 6-phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production.
      Title: Glucose 6-phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production.
    2. Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.
      Title: Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.
    3. An NADPH-independent mechanism enhances oxidative and nitrosative stress tolerance in yeast cells lacking glucose-6-phosphate dehydrogenase activity.
      Title: An NADPH-independent mechanism enhances oxidative and nitrosative stress tolerance in yeast cells lacking glucose-6-phosphate dehydrogenase activity.
    4. Glucose 6-phosphate and alcohol dehydrogenase activities are components of dynamic macromolecular depot structures.
      Title: Glucose 6-phosphate and alcohol dehydrogenase activities are components of dynamic macromolecular depots structures.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADPH regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, oxidative branch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glucose-6-phosphate dehydrogenase
    NP_014158.1
    • Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adaptation to oxidative stress; negative regulator of nonselective autophagy, independent of Stb5p; protein abundance increases in response to DNA replication stress; homolog of human G6PD which is deficient in patients with hemolytic anemia; human G6PD can complement yeast zwf1 null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      196426..197943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183079.1 → NP_014158.1  TPA: glucose-6-phosphate dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014158.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0V2, E9P908, P11412
      UniProtKB/TrEMBL
      A0A8H4BXM1, A6ZRK2, B3LP80, B5VQG8, G2WLM5, N1NZZ8
      Conserved Domains (1) summary
      TIGR00871
      Location:10 → 489
      zwf; glucose-6-phosphate 1-dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11412.4

    Gene LinkOut

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