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    ubp3 ubiquitin hydrolase Ubp3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541378, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ubp3
    Official Full Name
    ubiquitin hydrolase Ubp3
    Primary source
    PomBase:SPBP8B7.21
    Locus tag
    SPOM_SPBP8B7.21
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See ubp3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (3677649..3679661)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene histone H2A-H2B chaperone, FACT complex subunit Spt16 Neighboring gene RNA methyltransferase Nop2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene HDEL receptor Neighboring gene ubiquitin-protein ligase E3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin. Reyes-Turcu FE, et al. Nat Struct Mol Biol, 2011 Sep 4. PMID 21892171, Free PMC Article
    2. Analysis of stress granule assembly in Schizosaccharomyces pombe. Wang CY, et al. RNA, 2012 Apr. PMID 22328580, Free PMC Article
    3. The exocyst subunit Sec3 is regulated by a protein quality control pathway. Kampmeyer C, et al. J Biol Chem, 2017 Sep 15. PMID 28765280, Free PMC Article
    4. A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability. Kriegenburg F, et al. PLoS Genet, 2014 Jan. PMID 24497846, Free PMC Article
    5. Fission Yeast Puf2, a Pumilio and FBF Family RNA-Binding Protein, Links Stress Granules to Processing Bodies. Hsiao WY, et al. Mol Cell Biol, 2020 Apr 13. PMID 32071154, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables metal-dependent deubiquitinase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasm protein quality control by the ubiquitin-proteasome system IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of retrograde vesicle-mediated transport, Golgi to ER ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasmic stress granule EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin hydrolase Ubp3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3677649..3679661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022449.3 → NP_596528.1  ubiquitin hydrolase Ubp3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596528.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94269
      Conserved Domains (2) summary
      cd02257
      Location:134 → 508
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:132 → 508
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version

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