PTP2 tyrosine protein phosphatase PTP2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PTP2
Official Full Name: tyrosine protein phosphatase PTP2
Primary source: SGD:S000005734
Locus tag: YOR208W
See related: AllianceGenome:SGD:S000005734; FungiDB:YOR208W; VEuPathDB:YOR208W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of cell wall integrity MAPK cascade; peptidyl-tyrosine dephosphorylation; and response to pheromone triggering conjugation with cellular fusion. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PTP2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (733925..736177)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A rate threshold mechanism regulates MAPK stress signaling and survival.
Title: A rate threshold mechanism regulates MAPK stress signaling and survival.
PTP2 and MSG5 are key regulatory PPases that prevent over-activation of the calcium-induced signaling cascade under the parallel control of the SLT2 and calcineurin pathways.
Title: Functionally redundant protein phosphatase genes PTP2 and MSG5 co-regulate the calcium signaling pathway in Saccharomyces cerevisiae upon exposure to high extracellular calcium concentration.
Data discovered that six non-essential protein kinase (PKase) disruptions (Deltabck1, Deltamkk1, Deltaslt2/Deltampk1, Deltamck1, Deltassk2 and Deltayak1) suppressed the Cas-phenotype of the Deltaptp2 Deltamsg5 double disruptant.
Title: Identification of protein kinase disruptions as suppressors of the calcium sensitivity of S. cerevisiae Deltaptp2 Deltamsg5 protein phosphatase double disruptant.
These findings suggest that both Ptp2p and Msg5p are involved in the G1 to S transition and vacuole morphogenesis possibly through their regulation of Slt2 pathway.
Title: Yeast protein phosphatases Ptp2p and Msg5p are involved in G1-S transition, CLN2 transcription, and vacuole morphogenesis.
The Hog 1 common docking & PBD-2 docking sites are also involved in the specific interaction between Hog1 & Ptp2 and govern the dynamic dephosphorylation of activated Hog1.
Title: Two adjacent docking sites in the yeast Hog1 mitogen-activated protein (MAP) kinase differentially interact with the Pbs2 MAP kinase kinase and the Ptp2 protein tyrosine phosphatase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungal-type cell wall organization or biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fungal-type cell wall organization or biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell integrity MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in pheromone response MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of sporulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine protein phosphatase PTP2

NP_014851.3

EC 3.1.3.48

Phosphotyrosine-specific phosphatase; major role in osmolarity sensing through dephosphorylation of the Hog1p MAPK with a minor role by Ptp3p; inactivates and regulates Hog1p localization; major role in the cell wall integrity pathway through dephosphorylation of MAPK Slt2p with a minor role by Ptp3p; minor role with Msg5p in the pheromone adaptive response through dephosphorylation of MAPK Fus3p with major role by Ptp3p; co-regulates the calcium signaling pathway with Msg5p; nuclear localized

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

733925..736177

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183627.3 → NP_014851.3 TPA: tyrosine protein phosphatase PTP2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014851.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2R4, P29461

UniProtKB/TrEMBL

N1NYM7

Conserved Domains (1) summary

COG5599
Location:344 → 748

COG5599; Protein tyrosine phosphatase [Signal transduction mechanisms]