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    spo14 GDP/GTP exchange factor Spo14 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540996, updated on 18-Sep-2024

    Summary

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    Official Symbol
    spo14
    Official Full Name
    GDP/GTP exchange factor Spo14
    Primary source
    PomBase:SPBC3H7.01
    Locus tag
    SPOM_SPBC3H7.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPBP16F5.01c; stl1
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    Genomic context

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    See spo14 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003423.3 (1889972..1891843, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene sulfate transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transcription factor TFIIH complex cyclin Mcs2 Neighboring gene SAGA complex, phosphatidylinositol pseudokinase subunit Tra1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Live observation of forespore membrane formation in fission yeast. Nakamura T, et al. Mol Biol Cell, 2008 Aug. PMID 18550796, Free PMC Article
    2. The fission yeast spo14+ gene encoding a functional homologue of budding yeast Sec12 is required for the development of forespore membranes. Nakamura-Kubo M, et al. Mol Biol Cell, 2003 Mar. PMID 12631727, Free PMC Article
    3. Structural modification of spindle pole bodies during meiosis II is essential for the normal formation of ascospores in Schizosaccharomyces pombe: ultrastructural analysis of spo mutants. Hirata A, et al. Yeast, 1994 Feb. PMID 8203159
    4. A fission yeast SNAP-25 homologue, SpSec9, is essential for cytokinesis and sporulation. Nakamura T, et al. Cell Struct Funct, 2005. PMID 16272747
    5. High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library. Varberg JM, et al. G3 (Bethesda), 2020 Dec 3. PMID 33109728, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascospore-type prospore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascospore-type prospore membrane formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of COPII vesicle coating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GDP/GTP exchange factor Spo14

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1889972..1891843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356237.2 → NP_001342743.1  GDP/GTP exchange factor Spo14 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10659, Q9HFE9
      Conserved Domains (2) summary
      sd00039
      Location:167 → 199
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:112 → 324
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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