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    [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856270, updated on 11-Sep-2024

    Summary

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    Primary source
    SGD:S000006351
    Locus tag
    YPR147C
    See related
    AllianceGenome:SGD:S000006351; FungiDB:YPR147C; VEuPathDB:YPR147C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables triglyceride lipase activity. Involved in triglyceride catabolic process. Located in lipid droplet. Orthologous to human LDAH (lipid droplet associated hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (825645..826559, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene asparagine synthase (glutamine-hydrolyzing) 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nce102p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular modeling, docking and dynamics analysis of lipid droplet associated enzyme Ypr147cp from Saccharomyces cerevisiae. Sesham K, et al. Bioinformation, 2021. PMID 34393428, Free PMC Article
    2. Saccharomyces cerevisiae lipid droplet associated enzyme Ypr147cp shows both TAG lipase and ester hydrolase activities. M NK, et al. J Gen Appl Microbiol, 2018 May 21. PMID 29491250
    3. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. Currie E, et al. J Lipid Res, 2014 Jul. PMID 24868093, Free PMC Article
    4. Global protein expression profiling of budding yeast in response to DNA damage. Lee MW, et al. Yeast, 2007 Mar. PMID 17351896
    5. Reconstitution and protein composition analysis of endocytic actin patches. Michelot A, et al. Curr Biol, 2010 Nov 9. PMID 21035341, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triglyceride lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triglyceride lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid storage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional triacylglycerol lipase/ester hydrolase
    NP_015473.1
    • Bifunctional triacylglycerol lipase and short chain ester hydrolase; null mutant results in the accumulation of both triacylglycerol and fatty acids derived from neutral lipids and phospholipids as well as an increase in the quantity of lipid droplets; contains an alpha/beta hydrolase domain with a conserved GXSXG lipase motif; localizes to lipid droplets; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      825645..826559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184244.1 → NP_015473.1  TPA: bifunctional triacylglycerol lipase/ester hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015473.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4E4, Q06522
      UniProtKB/TrEMBL
      A6ZX23, B3LKA7, C8ZJH1, G2WPW0, N1NXU0
      Conserved Domains (1) summary
      pfam10230
      Location:30 → 292
      LIDHydrolase; Lipid-droplet associated hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06522.1

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