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    BUD3 Bud3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850345, updated on 17-May-2024

    Summary

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    Gene symbol
    BUD3
    Gene description
    Bud3p
    Primary source
    FungiDB:YCL014W
    Locus tag
    YCL014W
    See related
    SGD:S000000520; AllianceGenome:SGD:S000000520; VEuPathDB:YCL014W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YCL012W
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in axial cellular bud site selection; cytogamy; and positive regulation of GTPase activity. Located in cellular bud neck contractile ring. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BUD3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (96281..101191)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene cysteine desulfurase Neighboring gene Dcc1p Neighboring gene uncharacterized protein Neighboring gene single-stranded telomeric DNA-binding/mRNA-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of an amphipathic helix important for the formation of ectopic septin spirals and axial budding in yeast axial landmark protein Bud3p. Guo J, et al. PLoS One, 2011 Mar 8. PMID 21408200, Free PMC Article
    2. Critical Roles of a RhoGEF-Anillin Module in Septin Architectural Remodeling during Cytokinesis. Chen X, et al. Curr Biol, 2020 Apr 20. PMID 32197082, Free PMC Article
    3. Cell cycle programs of gene expression control morphogenetic protein localization. Lord M, et al. J Cell Biol, 2000 Dec 25. PMID 11134078, Free PMC Article
    4. Coupling of septins to the axial landmark by Bud4 in budding yeast. Kang PJ, et al. J Cell Sci, 2013 Mar 1. PMID 23345395, Free PMC Article
    5. Role of Bud3p in producing the axial budding pattern of yeast. Chant J, et al. J Cell Biol, 1995 May. PMID 7730410, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Critical Roles of a RhoGEF-Anillin Module in Septin Architectural Remodeling during Cytokinesis.
      Title: Critical Roles of a RhoGEF-Anillin Module in Septin Architectural Remodeling during Cytokinesis.
    2. Cell polarization in Saccharomyces cerevisiae, to a proper growth site, requires activation of Cdc42 by Bud3.
      Title: Bud3 activates Cdc42 to establish a proper growth site in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axial cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytogamy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bud3p
    NP_009914.2
    • Guanine nucleotide exchange factor (GEF) for Cdc42p; activates Cdc42p in early G1, accounting for the first stage of biphasic activation, with Cdc24p accounting for the second stage in late G1; involved in the Cdc42p-mediated assembly of the axial landmark that dictates the site for the next round of budding, resulting in the axial budding pattern in haploids; localizes with septins to the bud neck contractile ring in mitosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      96281..101191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178662.1 → NP_009914.2  TPA: Bud3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009914.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQZ9, P25556, P25557, P25558, P87007
      UniProtKB/TrEMBL
      A0A8H4BSL2, A6ZTH1, C7GQK5, N1PAP5
      Conserved Domains (2) summary
      smart00325
      Location:265 → 441
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam12015
      Location:27 → 205
      DUF3507; Domain of unknown function (DUF3507)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25558.2

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