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    MSH5 MutS family protein MSH5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851401, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MSH5
    Official Full Name
    MutS family protein MSH5
    Primary source
    SGD:S000002313
    Locus tag
    YDL154W
    See related
    AllianceGenome:SGD:S000002313; FungiDB:YDL154W; VEuPathDB:YDL154W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to DNA binding activity. Involved in reciprocal meiotic recombination. Located in nuclear chromosome. Part of MutSgamma complex. Used to study primary ovarian insufficiency. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; primary ovarian insufficiency 13; and spermatogenic failure 74. Orthologous to human MSH5 (mutS homolog 5). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MSH5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (178334..181039)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cmr1p Neighboring gene B-type cyclin CLB3 Neighboring gene rRNA-processing protein SAS10 Neighboring gene DNA-directed RNA polymerase III subunit C53

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterozygosity alters Msh5 binding to meiotic chromosomes in the baker's yeast. Dash S, et al. Genetics, 2024 Mar 6. PMID 38124392
    2. A single amino acid substitution in MSH5 results in DNA alkylation tolerance. Bawa S, et al. Gene, 2003 Oct 2. PMID 14557077
    3. A mutation in the MSH5 gene results in alkylation tolerance. Bawa S, et al. Cancer Res, 1997 Jul 1. PMID 9205082
    4. MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair. Hollingsworth NM, et al. Genes Dev, 1995 Jul 15. PMID 7622037
    5. Structural insights into Saccharomyces cerevisiae Msh4-Msh5 complex function using homology modeling. Rakshambikai R, et al. PLoS One, 2013. PMID 24244354, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Heterozygosity alters Msh5 binding to meiotic chromosomes in the baker's yeast.
      Title: Heterozygosity alters Msh5 binding to meiotic chromosomes in the baker's yeast.
    2. Regulation of Msh4-Msh5 association with meiotic chromosomes in budding yeast.
      Title: Regulation of Msh4-Msh5 association with meiotic chromosomes in budding yeast.
    3. a structural rationale for the meiotic defects observed in the msh4/5 point mutations. The mutations are likely to affect stability of the Msh4/5 proteins and/or interactions with DNA.
      Title: Structural insights into Saccharomyces cerevisiae Msh4-Msh5 complex function using homology modeling.
    4. Msh4 and msh5 mutants displayed reduced crossing over in meiosis but maintained wild-type spore viability.
      Title: Genetic analysis of baker's yeast Msh4-Msh5 reveals a threshold crossover level for meiotic viability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to D-loop DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to Y-form DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to four-way junction DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chiasma assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiosis I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MutSgamma complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MutS family protein MSH5
    NP_010127.1
    • Protein of the MutS family; forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      178334..181039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180214.1 → NP_010127.1  TPA: MutS family protein MSH5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010127.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRJ6, Q12175
      UniProtKB/TrEMBL
      G2WC09
      Conserved Domains (1) summary
      COG0249
      Location:1 → 898
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12175.1

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